PP2D1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf40	PP2D1	ENSP00000317671	ENSP00000373702	Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40.	Protein phosphatase 2C like domain containing 1.	0.523
DUSP21	FAM166A	ENSP00000343244	ENSP00000344729	Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.	Protein FAM166A; Family with sequence similarity 166 member A.	0.580
DUSP21	PP2D1	ENSP00000343244	ENSP00000373702	Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.	Protein phosphatase 2C like domain containing 1.	0.465
FAM166A	DUSP21	ENSP00000344729	ENSP00000343244	Protein FAM166A; Family with sequence similarity 166 member A.	Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.	0.580
FAM166A	PP2D1	ENSP00000344729	ENSP00000373702	Protein FAM166A; Family with sequence similarity 166 member A.	Protein phosphatase 2C like domain containing 1.	0.405
FAM166A	WDR90	ENSP00000344729	ENSP00000293879	Protein FAM166A; Family with sequence similarity 166 member A.	WD repeat-containing protein 90; Required for efficient primary cilium formation.	0.714
MTFMT	PP2D1	ENSP00000220058	ENSP00000373702	Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).	Protein phosphatase 2C like domain containing 1.	0.413
MTFMT	PPTC7	ENSP00000220058	ENSP00000346255	Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).	Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation.	0.413
PP2D1	C12orf40	ENSP00000373702	ENSP00000317671	Protein phosphatase 2C like domain containing 1.	Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40.	0.523
PP2D1	DUSP21	ENSP00000373702	ENSP00000343244	Protein phosphatase 2C like domain containing 1.	Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.	0.465
PP2D1	FAM166A	ENSP00000373702	ENSP00000344729	Protein phosphatase 2C like domain containing 1.	Protein FAM166A; Family with sequence similarity 166 member A.	0.405
PP2D1	MTFMT	ENSP00000373702	ENSP00000220058	Protein phosphatase 2C like domain containing 1.	Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).	0.413
PP2D1	PPM1H	ENSP00000373702	ENSP00000228705	Protein phosphatase 2C like domain containing 1.	Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.	0.410
PP2D1	PPM1J	ENSP00000373702	ENSP00000308926	Protein phosphatase 2C like domain containing 1.	Protein phosphatase, Mg2+/Mn2+ dependent 1J; Belongs to the PP2C family.	0.442
PP2D1	PPM1M	ENSP00000373702	ENSP00000387046	Protein phosphatase 2C like domain containing 1.	Protein phosphatase, Mg2+/Mn2+ dependent 1M.	0.432
PP2D1	PPTC7	ENSP00000373702	ENSP00000346255	Protein phosphatase 2C like domain containing 1.	Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation.	0.477
PP2D1	PRR19	ENSP00000373702	ENSP00000445247	Protein phosphatase 2C like domain containing 1.	Proline-rich protein 19; Proline rich 19.	0.456
PP2D1	WDR90	ENSP00000373702	ENSP00000293879	Protein phosphatase 2C like domain containing 1.	WD repeat-containing protein 90; Required for efficient primary cilium formation.	0.417
PPM1H	PP2D1	ENSP00000228705	ENSP00000373702	Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.	Protein phosphatase 2C like domain containing 1.	0.410
PPM1H	PPM1J	ENSP00000228705	ENSP00000308926	Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.	Protein phosphatase, Mg2+/Mn2+ dependent 1J; Belongs to the PP2C family.	0.814