node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB3 | PNO1 | ENSP00000499751 | ENSP00000263657 | Ankyrin repeat and SOCS box protein 3; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Belongs to the ankyrin SOCS box (ASB) family. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | 0.433 |
ASB3 | VPS9D1 | ENSP00000499751 | ENSP00000374037 | Ankyrin repeat and SOCS box protein 3; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Belongs to the ankyrin SOCS box (ASB) family. | VPS9 domain containing 1. | 0.467 |
CHMP1A | DBNDD1 | ENSP00000380998 | ENSP00000457625 | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | Dysbindin domain containing 1. | 0.414 |
CHMP1A | VPS9D1 | ENSP00000380998 | ENSP00000374037 | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | VPS9 domain containing 1. | 0.495 |
DBNDD1 | CHMP1A | ENSP00000457625 | ENSP00000380998 | Dysbindin domain containing 1. | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | 0.414 |
DBNDD1 | SPATA2L | ENSP00000457625 | ENSP00000289805 | Dysbindin domain containing 1. | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like. | 0.489 |
DBNDD1 | VPS9D1 | ENSP00000457625 | ENSP00000374037 | Dysbindin domain containing 1. | VPS9 domain containing 1. | 0.512 |
DBNDD1 | ZNF276 | ENSP00000457625 | ENSP00000415836 | Dysbindin domain containing 1. | Zinc finger protein 276; May be involved in transcriptional regulation. | 0.464 |
DDX39A | DTX2 | ENSP00000242776 | ENSP00000322885 | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family. | 0.416 |
DDX39A | VPS9D1 | ENSP00000242776 | ENSP00000374037 | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | VPS9 domain containing 1. | 0.569 |
DTX2 | DDX39A | ENSP00000322885 | ENSP00000242776 | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family. | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | 0.416 |
DTX2 | VPS9D1 | ENSP00000322885 | ENSP00000374037 | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family. | VPS9 domain containing 1. | 0.503 |
NAV3 | PDX1 | ENSP00000381007 | ENSP00000370421 | Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. | Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development [...] | 0.610 |
NAV3 | VPS9D1 | ENSP00000381007 | ENSP00000374037 | Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. | VPS9 domain containing 1. | 0.610 |
PDX1 | NAV3 | ENSP00000370421 | ENSP00000381007 | Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development [...] | Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. | 0.610 |
PDX1 | VPS9D1 | ENSP00000370421 | ENSP00000374037 | Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development [...] | VPS9 domain containing 1. | 0.610 |
PNO1 | ASB3 | ENSP00000263657 | ENSP00000499751 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | Ankyrin repeat and SOCS box protein 3; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Belongs to the ankyrin SOCS box (ASB) family. | 0.433 |
PNO1 | VPS9D1 | ENSP00000263657 | ENSP00000374037 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | VPS9 domain containing 1. | 0.455 |
SPATA2L | DBNDD1 | ENSP00000289805 | ENSP00000457625 | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like. | Dysbindin domain containing 1. | 0.489 |
SPATA2L | VPS9D1 | ENSP00000289805 | ENSP00000374037 | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like. | VPS9 domain containing 1. | 0.797 |