node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GHRH | MRGPRE | ENSP00000362716 | ENSP00000374482 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.468 |
GPR139 | MRGPRD | ENSP00000458791 | ENSP00000310631 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.487 |
GPR139 | MRGPRE | ENSP00000458791 | ENSP00000374482 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.480 |
MRGPRD | GPR139 | ENSP00000310631 | ENSP00000458791 | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.487 |
MRGPRD | MRGPRE | ENSP00000310631 | ENSP00000374482 | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.452 |
MRGPRD | NPFF | ENSP00000310631 | ENSP00000267017 | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. | 0.864 |
MRGPRE | GHRH | ENSP00000374482 | ENSP00000362716 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. | 0.468 |
MRGPRE | GPR139 | ENSP00000374482 | ENSP00000458791 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.480 |
MRGPRE | MRGPRD | ENSP00000374482 | ENSP00000310631 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.452 |
MRGPRE | NPFF | ENSP00000374482 | ENSP00000267017 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. | 0.710 |
MRGPRE | STMND1 | ENSP00000374482 | ENSP00000455698 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | Stathmin domain containing 1. | 0.418 |
NPFF | MRGPRD | ENSP00000267017 | ENSP00000310631 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G- protein G(q) and G(i); Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.864 |
NPFF | MRGPRE | ENSP00000267017 | ENSP00000374482 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.710 |
STMND1 | MRGPRE | ENSP00000455698 | ENSP00000374482 | Stathmin domain containing 1. | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily. | 0.418 |