node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf87 | TMEM87A | ENSP00000331581 | ENSP00000374484 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.448 |
CCDC84 | DYNC1LI2 | ENSP00000334767 | ENSP00000258198 | Coiled-coil domain-containing protein 84. | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes; Belongs to the dynein light intermediate chain family. | 0.509 |
CCDC84 | TEPSIN | ENSP00000334767 | ENSP00000490393 | Coiled-coil domain-containing protein 84. | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | 0.465 |
CCDC84 | TMEM87A | ENSP00000334767 | ENSP00000374484 | Coiled-coil domain-containing protein 84. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.479 |
CCDC84 | ZCCHC8 | ENSP00000334767 | ENSP00000438993 | Coiled-coil domain-containing protein 84. | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing (Probable); Belongs to the ZCCHC8 family. | 0.415 |
DYNC1LI2 | CCDC84 | ENSP00000258198 | ENSP00000334767 | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes; Belongs to the dynein light intermediate chain family. | Coiled-coil domain-containing protein 84. | 0.509 |
DYNC1LI2 | TMEM87A | ENSP00000258198 | ENSP00000374484 | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes; Belongs to the dynein light intermediate chain family. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.446 |
GPAA1 | TEPSIN | ENSP00000347206 | ENSP00000490393 | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | 0.469 |
GPAA1 | TMEM87A | ENSP00000347206 | ENSP00000374484 | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.527 |
GPAA1 | ZCCHC8 | ENSP00000347206 | ENSP00000438993 | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing (Probable); Belongs to the ZCCHC8 family. | 0.419 |
GPR107 | TMEM87A | ENSP00000361483 | ENSP00000374484 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.497 |
LMAN1 | RHOA | ENSP00000251047 | ENSP00000400175 | Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.595 |
LMAN1 | TMEM87A | ENSP00000251047 | ENSP00000374484 | Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.460 |
RHOA | LMAN1 | ENSP00000400175 | ENSP00000251047 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. | 0.595 |
RHOA | TMEM87A | ENSP00000400175 | ENSP00000374484 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.577 |
TEPSIN | CCDC84 | ENSP00000490393 | ENSP00000334767 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | Coiled-coil domain-containing protein 84. | 0.465 |
TEPSIN | GPAA1 | ENSP00000490393 | ENSP00000347206 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. | 0.469 |
TEPSIN | TMEM87A | ENSP00000490393 | ENSP00000374484 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | 0.508 |
TEPSIN | ZCCHC8 | ENSP00000490393 | ENSP00000438993 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing (Probable); Belongs to the ZCCHC8 family. | 0.470 |
TMEM87A | C11orf87 | ENSP00000374484 | ENSP00000331581 | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87. | 0.448 |