node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH5 | FAM168B | ENSP00000382091 | ENSP00000374565 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single- stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of targe [...] | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.434 |
AMER3 | FAM168B | ENSP00000392700 | ENSP00000374565 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.430 |
AMER3 | GPR148 | ENSP00000392700 | ENSP00000308908 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Probable G-protein coupled receptor 148; Orphan receptor. | 0.573 |
CD180 | FAM168B | ENSP00000256447 | ENSP00000374565 | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.413 |
CMTM4 | FAM168B | ENSP00000333833 | ENSP00000374565 | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. Belongs to the chemokine-like factor family. | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.476 |
FAM168B | ALKBH5 | ENSP00000374565 | ENSP00000382091 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single- stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of targe [...] | 0.434 |
FAM168B | AMER3 | ENSP00000374565 | ENSP00000392700 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | 0.430 |
FAM168B | CD180 | ENSP00000374565 | ENSP00000256447 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | 0.413 |
FAM168B | CMTM4 | ENSP00000374565 | ENSP00000333833 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation. Belongs to the chemokine-like factor family. | 0.476 |
FAM168B | FUBP3 | ENSP00000374565 | ENSP00000318177 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | Far upstream element-binding protein 3; May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. | 0.449 |
FAM168B | GAGE12H | ENSP00000374565 | ENSP00000371141 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | G antigen 12H. | 0.445 |
FAM168B | GPR107 | ENSP00000374565 | ENSP00000361483 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.631 |
FAM168B | GPR148 | ENSP00000374565 | ENSP00000308908 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | Probable G-protein coupled receptor 148; Orphan receptor. | 0.406 |
FAM168B | RTN4R | ENSP00000374565 | ENSP00000043402 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain develo [...] | 0.677 |
FAM168B | WSB2 | ENSP00000374565 | ENSP00000409131 | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | WD repeat and SOCS box-containing protein 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.473 |
FUBP3 | FAM168B | ENSP00000318177 | ENSP00000374565 | Far upstream element-binding protein 3; May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.449 |
FUBP3 | GPR107 | ENSP00000318177 | ENSP00000361483 | Far upstream element-binding protein 3; May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.473 |
GAGE12H | FAM168B | ENSP00000371141 | ENSP00000374565 | G antigen 12H. | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.445 |
GPR107 | FAM168B | ENSP00000361483 | ENSP00000374565 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. | 0.631 |
GPR107 | FUBP3 | ENSP00000361483 | ENSP00000318177 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Far upstream element-binding protein 3; May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. | 0.473 |