| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CXorf40B | KHDC1 | ENSP00000359434 | ENSP00000359411 | Protein CXorf40B. | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. | 0.416 |
| CXorf40B | ZSCAN5A | ENSP00000359434 | ENSP00000375593 | Protein CXorf40B. | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation. | 0.540 |
| KDM1A | RCOR1 | ENSP00000383042 | ENSP00000262241 | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | 0.999 |
| KDM1A | ZMYM2 | ENSP00000383042 | ENSP00000479904 | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.969 |
| KDM1A | ZMYM3 | ENSP00000383042 | ENSP00000322845 | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.908 |
| KDM1A | ZMYM4 | ENSP00000383042 | ENSP00000322915 | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.607 |
| KDM1A | ZSCAN5A | ENSP00000383042 | ENSP00000375593 | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation. | 0.472 |
| KHDC1 | CXorf40B | ENSP00000359411 | ENSP00000359434 | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. | Protein CXorf40B. | 0.416 |
| KHDC1 | TRIM43 | ENSP00000359411 | ENSP00000272395 | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. | Tripartite motif containing 43. | 0.697 |
| KHDC1 | ZSCAN5A | ENSP00000359411 | ENSP00000375593 | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation. | 0.448 |
| RCOR1 | KDM1A | ENSP00000262241 | ENSP00000383042 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | 0.999 |
| RCOR1 | ZMYM2 | ENSP00000262241 | ENSP00000479904 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.957 |
| RCOR1 | ZMYM3 | ENSP00000262241 | ENSP00000322845 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.834 |
| RCOR1 | ZMYM4 | ENSP00000262241 | ENSP00000322915 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.765 |
| RCOR1 | ZSCAN5A | ENSP00000262241 | ENSP00000375593 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation. | 0.442 |
| TRIM43 | KHDC1 | ENSP00000272395 | ENSP00000359411 | Tripartite motif containing 43. | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family. | 0.697 |
| TRIM43 | ZSCAN5A | ENSP00000272395 | ENSP00000375593 | Tripartite motif containing 43. | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation. | 0.427 |
| ZMYM2 | KDM1A | ENSP00000479904 | ENSP00000383042 | Zinc finger MYM-type protein 2; May function as a transcription factor. | Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] | 0.969 |
| ZMYM2 | RCOR1 | ENSP00000479904 | ENSP00000262241 | Zinc finger MYM-type protein 2; May function as a transcription factor. | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] | 0.957 |
| ZMYM2 | ZMYM3 | ENSP00000479904 | ENSP00000322845 | Zinc finger MYM-type protein 2; May function as a transcription factor. | Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.867 |