OTOS protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACYP2	OTOS	ENSP00000475986	ENSP00000375849	Acylphosphatase-2; Its physiological role is not yet clear.	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.441
CLLU1OS	LDLRAD2	ENSP00000367748	ENSP00000340988	Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.	Low density lipoprotein receptor class A domain containing 2.	0.846
CLLU1OS	OTOS	ENSP00000367748	ENSP00000375849	Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.853
GPR160	OTOS	ENSP00000348161	ENSP00000375849	Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.452
GPR160	SAMD7	ENSP00000348161	ENSP00000391299	Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.	0.523
LDLRAD2	CLLU1OS	ENSP00000340988	ENSP00000367748	Low density lipoprotein receptor class A domain containing 2.	Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.	0.846
LDLRAD2	OTOS	ENSP00000340988	ENSP00000375849	Low density lipoprotein receptor class A domain containing 2.	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.725
OTOG	OTOS	ENSP00000382323	ENSP00000375849	Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.444
OTOG	SLC26A4	ENSP00000382323	ENSP00000494017	Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.511
OTOG	TECTA	ENSP00000382323	ENSP00000376543	Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals.	0.460
OTOG	TECTB	ENSP00000382323	ENSP00000494896	Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals.	0.957
OTOR	OTOS	ENSP00000246081	ENSP00000375849	Otoraplin; Belongs to the MIA/OTOR family.	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	0.441
OTOS	ACYP2	ENSP00000375849	ENSP00000475986	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Acylphosphatase-2; Its physiological role is not yet clear.	0.441
OTOS	CLLU1OS	ENSP00000375849	ENSP00000367748	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.	0.853
OTOS	GPR160	ENSP00000375849	ENSP00000348161	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.452
OTOS	LDLRAD2	ENSP00000375849	ENSP00000340988	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Low density lipoprotein receptor class A domain containing 2.	0.725
OTOS	OTOG	ENSP00000375849	ENSP00000382323	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	0.444
OTOS	OTOR	ENSP00000375849	ENSP00000246081	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Otoraplin; Belongs to the MIA/OTOR family.	0.441
OTOS	SAMD7	ENSP00000375849	ENSP00000391299	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.	0.475
OTOS	SLC26A4	ENSP00000375849	ENSP00000494017	Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.482