node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDH23 | OTOA | ENSP00000224721 | ENSP00000496564 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | 0.598 |
CDH23 | OTOG | ENSP00000224721 | ENSP00000382323 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | 0.589 |
CDH23 | OTOS | ENSP00000224721 | ENSP00000375849 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.624 |
CDH23 | TECTA | ENSP00000224721 | ENSP00000376543 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.409 |
COCH | OTOA | ENSP00000216361 | ENSP00000496564 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | 0.511 |
COCH | OTOG | ENSP00000216361 | ENSP00000382323 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | 0.429 |
COCH | OTOS | ENSP00000216361 | ENSP00000375849 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.479 |
COCH | TECTA | ENSP00000216361 | ENSP00000376543 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.782 |
COCH | TECTB | ENSP00000216361 | ENSP00000494896 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.902 |
ENSA | OTOS | ENSP00000341743 | ENSP00000375849 | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.444 |
GPR160 | OTOS | ENSP00000348161 | ENSP00000375849 | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.468 |
GPR160 | SAMD7 | ENSP00000348161 | ENSP00000391299 | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes. | 0.529 |
OTOA | CDH23 | ENSP00000496564 | ENSP00000224721 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | 0.598 |
OTOA | COCH | ENSP00000496564 | ENSP00000216361 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.511 |
OTOA | OTOG | ENSP00000496564 | ENSP00000382323 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | 0.955 |
OTOA | OTOR | ENSP00000496564 | ENSP00000246081 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Otoraplin; Belongs to the MIA/OTOR family. | 0.431 |
OTOA | OTOS | ENSP00000496564 | ENSP00000375849 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.537 |
OTOA | TECTA | ENSP00000496564 | ENSP00000376543 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.930 |
OTOA | TECTB | ENSP00000496564 | ENSP00000494896 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.925 |
OTOG | CDH23 | ENSP00000382323 | ENSP00000224721 | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | 0.589 |