| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD13B | EML1 | ENSP00000378328 | ENSP00000334314 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se; Belongs to the WD repeat EMAP family. | 0.449 |
| ANKRD13B | RTN4RL2 | ENSP00000378328 | ENSP00000335397 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] | 0.491 |
| ANKRD13B | SEZ6L2 | ENSP00000378328 | ENSP00000481917 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.473 |
| ANKRD13B | TMEM25 | ENSP00000378328 | ENSP00000431548 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.533 |
| ANKRD13B | TMEM91 | ENSP00000378328 | ENSP00000375859 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.534 |
| B9D2 | TMEM91 | ENSP00000243578 | ENSP00000375859 | B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes; Belongs to the B9D family. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.551 |
| EML1 | ANKRD13B | ENSP00000334314 | ENSP00000378328 | Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se; Belongs to the WD repeat EMAP family. | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.449 |
| EML1 | TMEM25 | ENSP00000334314 | ENSP00000431548 | Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se; Belongs to the WD repeat EMAP family. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.444 |
| EML1 | TMEM91 | ENSP00000334314 | ENSP00000375859 | Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se; Belongs to the WD repeat EMAP family. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.452 |
| GSG1L2 | TMEM91 | ENSP00000465978 | ENSP00000375859 | Germ cell-specific gene 1-like protein 2; GSG1 like 2. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.617 |
| PRRT1B | TMEM233 | ENSP00000490857 | ENSP00000403130 | Proline rich transmembrane protein 1B. | Transmembrane protein 233. | 0.547 |
| PRRT1B | TMEM91 | ENSP00000490857 | ENSP00000375859 | Proline rich transmembrane protein 1B. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.553 |
| PRRT1B | TRARG1 | ENSP00000490857 | ENSP00000329548 | Proline rich transmembrane protein 1B. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. | 0.446 |
| RTN4RL2 | ANKRD13B | ENSP00000335397 | ENSP00000378328 | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.491 |
| RTN4RL2 | TMEM25 | ENSP00000335397 | ENSP00000431548 | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.456 |
| RTN4RL2 | TMEM91 | ENSP00000335397 | ENSP00000375859 | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.460 |
| SEZ6L2 | ANKRD13B | ENSP00000481917 | ENSP00000378328 | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.473 |
| SEZ6L2 | TMEM25 | ENSP00000481917 | ENSP00000431548 | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.444 |
| SEZ6L2 | TMEM91 | ENSP00000481917 | ENSP00000375859 | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | Transmembrane protein 91; Belongs to the CD225/Dispanin family. | 0.455 |
| TMEM233 | PRRT1B | ENSP00000403130 | ENSP00000490857 | Transmembrane protein 233. | Proline rich transmembrane protein 1B. | 0.547 |