STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MB21D2Protein MB21D2; Mab-21 domain containing 2. (491 aa)    
Predicted Functional Partners:
MAB21L3
Protein mab-21-like 3; Mab-21 like 3.
      
 0.601
TOX4
TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
      
 0.548
C3orf70
UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development.
      
 0.471
ITPRIPL2
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2.
   
  
 0.462
MROH2B
Maestro heat-like repeat-containing protein family member 2B; May play a role in the process of sperm capacitation.
      
 0.451
TBC1D12
TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth.
      
 0.443
CDH1
Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
    
 
 0.433
CDH17
Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
      
 0.424
NOVA1
RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.
      
 0.420
OR52J3
Olfactory receptor 52J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.