STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TEDC1Tubulin epsilon and delta complex protein 1; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F. (426 aa)    
Predicted Functional Partners:
TEDC2
Tubulin epsilon and delta complex protein 2; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.
   
 
 0.860
TUBE1
Tubulin epsilon 1; Belongs to the tubulin family.
   
 
 0.771
DDIT3
DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]
    
   0.614
C22orf31
Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.
      
 0.541
TMEM121
Transmembrane protein 121; May play a role in MAPK signaling. Belongs to the TMEM121 family.
   
  
 0.526
CEP44
Centrosomal protein 44.
      
 0.511
C19orf25
UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family.
   
  
 0.482
TUBD1
Tubulin delta chain; Acts as a positive regulator of hedgehog signaling and regulates ciliary function; Belongs to the tubulin family.
      
 0.448
JADE2
E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).
   
   0.422
RTTN
Rotatin; Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
   
  
 0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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