node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD300A | CD300C | ENSP00000353259 | ENSP00000329507 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | 0.719 |
CD300A | CD300E | ENSP00000353259 | ENSP00000376395 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.646 |
CD300A | CD300LB | ENSP00000353259 | ENSP00000376397 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. | 0.821 |
CD300A | CD300LD | ENSP00000353259 | ENSP00000364501 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 5; CD300 molecule like family member d. | 0.629 |
CD300A | CD300LF | ENSP00000353259 | ENSP00000462309 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to cer [...] | 0.762 |
CD300A | FCER1G | ENSP00000353259 | ENSP00000289902 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] | 0.574 |
CD300A | TREM1 | ENSP00000353259 | ENSP00000244709 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. | 0.657 |
CD300A | TREML4 | ENSP00000353259 | ENSP00000342570 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages. | 0.484 |
CD300A | TYROBP | ENSP00000353259 | ENSP00000262629 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation ; [...] | 0.745 |
CD300C | CD300A | ENSP00000329507 | ENSP00000353259 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | 0.719 |
CD300C | CD300E | ENSP00000329507 | ENSP00000376395 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 2; Probably acts as an activating receptor. | 0.639 |
CD300C | CD300LB | ENSP00000329507 | ENSP00000376397 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. | 0.939 |
CD300C | CD300LD | ENSP00000329507 | ENSP00000364501 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 5; CD300 molecule like family member d. | 0.446 |
CD300C | CD300LF | ENSP00000329507 | ENSP00000462309 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to cer [...] | 0.815 |
CD300C | FCER1G | ENSP00000329507 | ENSP00000289902 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] | 0.835 |
CD300C | TREM1 | ENSP00000329507 | ENSP00000244709 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. | 0.620 |
CD300C | TREML4 | ENSP00000329507 | ENSP00000342570 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages. | 0.498 |
CD300C | TYROBP | ENSP00000329507 | ENSP00000262629 | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation ; [...] | 0.826 |
CD300E | CD300A | ENSP00000376395 | ENSP00000353259 | CMRF35-like molecule 2; Probably acts as an activating receptor. | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. | 0.646 |
CD300E | CD300C | ENSP00000376395 | ENSP00000329507 | CMRF35-like molecule 2; Probably acts as an activating receptor. | CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family. | 0.639 |