Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CUZD1CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. (607 aa)    
Predicted Functional Partners:
CTRC
Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
   
 
 0.952
CELA3B
Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity.
   
 
 0.950
CELA3A
Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.
   
 
 0.949
PLA2G1B
Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family.
   
  
 0.943
GP2
Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2.
   
 
0.897
CPB1
Carboxypeptidase B1; Belongs to the peptidase M14 family.
   
  
 0.814
CELA2A
Chymotrypsin-like elastase family member 2A; Acts upon elastin.
   
 
 0.812
CTRB2
Chymotrypsinogen B2; Belongs to the peptidase S1 family.
   
   0.767
CTRB1
Chymotrypsinogen B1; Belongs to the peptidase S1 family.
   
 
 0.764
CELA2B
Chymotrypsin-like elastase family member 2B; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.
   
 
 0.752
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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