node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMCES | RNF208 | ENSP00000372955 | ENSP00000376572 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonu [...] | Ring finger protein 208. | 0.541 |
HMCES | STPG1 | ENSP00000372955 | ENSP00000363530 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonu [...] | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. | 0.507 |
OR4F21 | RNF208 | ENSP00000318878 | ENSP00000376572 | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Ring finger protein 208. | 0.479 |
OR4F21 | ZNF487 | ENSP00000318878 | ENSP00000498490 | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Putative zinc finger protein 487; May be involved in transcriptional regulation. | 0.581 |
POMGNT2 | RNF208 | ENSP00000344125 | ENSP00000376572 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] | Ring finger protein 208. | 0.531 |
POMGNT2 | STPG1 | ENSP00000344125 | ENSP00000363530 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. | 0.505 |
RNF208 | HMCES | ENSP00000376572 | ENSP00000372955 | Ring finger protein 208. | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonu [...] | 0.541 |
RNF208 | OR4F21 | ENSP00000376572 | ENSP00000318878 | Ring finger protein 208. | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.479 |
RNF208 | POMGNT2 | ENSP00000376572 | ENSP00000344125 | Ring finger protein 208. | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] | 0.531 |
RNF208 | SLC44A3 | ENSP00000376572 | ENSP00000271227 | Ring finger protein 208. | Choline transporter-like protein 3; Solute carrier family 44 member 3. | 0.506 |
RNF208 | SMTNL1 | ENSP00000376572 | ENSP00000432651 | Ring finger protein 208. | Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). | 0.519 |
RNF208 | STPG1 | ENSP00000376572 | ENSP00000363530 | Ring finger protein 208. | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. | 0.642 |
RNF208 | TCTN1 | ENSP00000376572 | ENSP00000380779 | Ring finger protein 208. | Tectonic-1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to rep [...] | 0.519 |
RNF208 | ZNF487 | ENSP00000376572 | ENSP00000498490 | Ring finger protein 208. | Putative zinc finger protein 487; May be involved in transcriptional regulation. | 0.494 |
RNF208 | ZNF497 | ENSP00000376572 | ENSP00000311183 | Ring finger protein 208. | Zinc finger protein 497; May be involved in transcriptional regulation. | 0.589 |
RNF208 | ZNF575 | ENSP00000376572 | ENSP00000315870 | Ring finger protein 208. | Zinc finger protein 575; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.471 |
SLC44A3 | RNF208 | ENSP00000271227 | ENSP00000376572 | Choline transporter-like protein 3; Solute carrier family 44 member 3. | Ring finger protein 208. | 0.506 |
SLC44A3 | STPG1 | ENSP00000271227 | ENSP00000363530 | Choline transporter-like protein 3; Solute carrier family 44 member 3. | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. | 0.478 |
SMTNL1 | RNF208 | ENSP00000432651 | ENSP00000376572 | Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). | Ring finger protein 208. | 0.519 |
STPG1 | HMCES | ENSP00000363530 | ENSP00000372955 | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonu [...] | 0.507 |