Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAP3K19Mitogen-activated protein kinase kinase kinase 19. (1328 aa)    
Predicted Functional Partners:
C11orf88
UPF0722 protein C11orf88.
   
  
 0.541
FAM102B
Protein FAM102B; Family with sequence similarity 102 member B.
      
 0.496
TP53TG5
TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway.
   
  
 0.486
KRBA2
KRAB-A domain containing 2.
    
 
 0.478
ANKUB1
Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1.
   
  
 0.473
SLC4A9
Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex. Belongs to the anion exchanger (TC 2.A.31) family.
      
 0.465
HMBS
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family.
     
 0.465
ADGB
Androglobin.
   
  
 0.458
TSKS
Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
      
 0.455
DNAH9
Dynein heavy chain 9, axonemal; Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
   
  
 0.454
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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