node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPE | CYB561 | ENSP00000386104 | ENSP00000464215 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Belongs to the peptidase M14 family. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.591 |
CPE | PAM | ENSP00000386104 | ENSP00000306100 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Belongs to the peptidase M14 family. | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S st [...] | 0.719 |
CYB561 | CPE | ENSP00000464215 | ENSP00000386104 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Belongs to the peptidase M14 family. | 0.591 |
CYB561 | CYB561D2 | ENSP00000464215 | ENSP00000391209 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.548 |
CYB561 | CYBB | ENSP00000464215 | ENSP00000367851 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | 0.544 |
CYB561 | DBH | ENSP00000464215 | ENSP00000376776 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. | 0.846 |
CYB561 | FRRS1 | ENSP00000464215 | ENSP00000287474 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family. | 0.956 |
CYB561 | PAM | ENSP00000464215 | ENSP00000306100 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S st [...] | 0.870 |
CYB561 | SLC11A2 | ENSP00000464215 | ENSP00000378364 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Belongs to the NRAMP family. | 0.473 |
CYB561 | SLC31A1 | ENSP00000464215 | ENSP00000363329 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | 0.433 |
CYB561 | STEAP2 | ENSP00000464215 | ENSP00000378119 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity); Belongs to the STEAP family. | 0.428 |
CYB561 | STEAP3 | ENSP00000464215 | ENSP00000376822 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. | 0.528 |
CYB561D2 | CYB561 | ENSP00000391209 | ENSP00000464215 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.548 |
CYB561D2 | FRRS1 | ENSP00000391209 | ENSP00000287474 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family. | 0.642 |
CYBB | CYB561 | ENSP00000367851 | ENSP00000464215 | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.544 |
DBH | CYB561 | ENSP00000376776 | ENSP00000464215 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.846 |
FRRS1 | CYB561 | ENSP00000287474 | ENSP00000464215 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.956 |
FRRS1 | CYB561D2 | ENSP00000287474 | ENSP00000391209 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.642 |
PAM | CPE | ENSP00000306100 | ENSP00000386104 | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S st [...] | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Belongs to the peptidase M14 family. | 0.719 |
PAM | CYB561 | ENSP00000306100 | ENSP00000464215 | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S st [...] | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.870 |