RASGEF1C protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf115	LYZL4	ENSP00000294889	ENSP00000287748	Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	0.497
C1orf115	RASGEF1C	ENSP00000294889	ENSP00000377037	Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.487
C1orf115	TMEM244	ENSP00000294889	ENSP00000357125	Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.	Transmembrane protein 244.	0.530
HRAS	KRAS	ENSP00000407586	ENSP00000256078	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.	0.999
HRAS	NRAS	ENSP00000407586	ENSP00000358548	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.999
HRAS	RASGEF1C	ENSP00000407586	ENSP00000377037	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.476
ISOC1	RASGEF1C	ENSP00000173527	ENSP00000377037	Isochorismatase domain containing 1.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.472
KRAS	HRAS	ENSP00000256078	ENSP00000407586	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.999
KRAS	NRAS	ENSP00000256078	ENSP00000358548	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.999
KRAS	RASGEF1C	ENSP00000256078	ENSP00000377037	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.476
LYZL4	C1orf115	ENSP00000287748	ENSP00000294889	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.	0.497
LYZL4	RASGEF1C	ENSP00000287748	ENSP00000377037	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.486
LYZL4	TMEM244	ENSP00000287748	ENSP00000357125	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Transmembrane protein 244.	0.530
MAP10	RASGEF1C	ENSP00000403208	ENSP00000377037	Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.474
NRAS	HRAS	ENSP00000358548	ENSP00000407586	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.999
NRAS	KRAS	ENSP00000358548	ENSP00000256078	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.	0.999
NRAS	RASGEF1C	ENSP00000358548	ENSP00000377037	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	0.476
RASGEF1C	C1orf115	ENSP00000377037	ENSP00000294889	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.	0.487
RASGEF1C	HRAS	ENSP00000377037	ENSP00000407586	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.476
RASGEF1C	ISOC1	ENSP00000377037	ENSP00000173527	Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).	Isochorismatase domain containing 1.	0.472