node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKS1B | DIP2C | ENSP00000449629 | ENSP00000280886 | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | Disco interacting protein 2 homolog C. | 0.467 |
ANKS1B | DLEU7 | ENSP00000449629 | ENSP00000427177 | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | 0.427 |
ANKS1B | GASK1B | ENSP00000449629 | ENSP00000377396 | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.424 |
DIAPH2 | GASK1B | ENSP00000321348 | ENSP00000377396 | Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton; Belongs to the formin homology family. Diaphanous subfamily. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.414 |
DIP2C | ANKS1B | ENSP00000280886 | ENSP00000449629 | Disco interacting protein 2 homolog C. | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | 0.467 |
DIP2C | DLEU7 | ENSP00000280886 | ENSP00000427177 | Disco interacting protein 2 homolog C. | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | 0.443 |
DIP2C | GASK1B | ENSP00000280886 | ENSP00000377396 | Disco interacting protein 2 homolog C. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.442 |
DLEU7 | ANKS1B | ENSP00000427177 | ENSP00000449629 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | 0.427 |
DLEU7 | DIP2C | ENSP00000427177 | ENSP00000280886 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | Disco interacting protein 2 homolog C. | 0.443 |
DLEU7 | GASK1B | ENSP00000427177 | ENSP00000377396 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.449 |
FAM20A | FAM20C | ENSP00000468308 | ENSP00000322323 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | 0.998 |
FAM20A | GASK1B | ENSP00000468308 | ENSP00000377396 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.524 |
FAM20B | GASK1B | ENSP00000263733 | ENSP00000377396 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalyti [...] | Golgi associated kinase 1B; Belongs to the GASK family. | 0.468 |
FAM20C | FAM20A | ENSP00000322323 | ENSP00000468308 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.998 |
FAM20C | GASK1B | ENSP00000322323 | ENSP00000377396 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Golgi associated kinase 1B; Belongs to the GASK family. | 0.428 |
GASK1B | ANKS1B | ENSP00000377396 | ENSP00000449629 | Golgi associated kinase 1B; Belongs to the GASK family. | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. | 0.424 |
GASK1B | DIAPH2 | ENSP00000377396 | ENSP00000321348 | Golgi associated kinase 1B; Belongs to the GASK family. | Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton; Belongs to the formin homology family. Diaphanous subfamily. | 0.414 |
GASK1B | DIP2C | ENSP00000377396 | ENSP00000280886 | Golgi associated kinase 1B; Belongs to the GASK family. | Disco interacting protein 2 homolog C. | 0.442 |
GASK1B | DLEU7 | ENSP00000377396 | ENSP00000427177 | Golgi associated kinase 1B; Belongs to the GASK family. | Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7. | 0.449 |
GASK1B | FAM20A | ENSP00000377396 | ENSP00000468308 | Golgi associated kinase 1B; Belongs to the GASK family. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.524 |