| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C12orf29 | C12orf50 | ENSP00000349358 | ENSP00000298699 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | 0.694 |
| C12orf29 | GASK1B | ENSP00000349358 | ENSP00000377396 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.476 |
| C12orf29 | TMTC3 | ENSP00000349358 | ENSP00000266712 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. | 0.509 |
| C12orf29 | TSPAN19 | ENSP00000349358 | ENSP00000433816 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | Putative tetraspanin-19; Tetraspanin 19. | 0.560 |
| C12orf50 | C12orf29 | ENSP00000298699 | ENSP00000349358 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | 0.694 |
| C12orf50 | GASK1B | ENSP00000298699 | ENSP00000377396 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.513 |
| C12orf50 | TMTC3 | ENSP00000298699 | ENSP00000266712 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. | 0.524 |
| C12orf50 | TSPAN19 | ENSP00000298699 | ENSP00000433816 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | Putative tetraspanin-19; Tetraspanin 19. | 0.591 |
| DIAPH2 | GASK1B | ENSP00000321348 | ENSP00000377396 | Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton; Belongs to the formin homology family. Diaphanous subfamily. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.464 |
| FAM20A | GASK1B | ENSP00000468308 | ENSP00000377396 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.476 |
| FAM20B | GASK1B | ENSP00000263733 | ENSP00000377396 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalyti [...] | Golgi associated kinase 1B; Belongs to the GASK family. | 0.442 |
| GASK1B | C12orf29 | ENSP00000377396 | ENSP00000349358 | Golgi associated kinase 1B; Belongs to the GASK family. | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29. | 0.476 |
| GASK1B | C12orf50 | ENSP00000377396 | ENSP00000298699 | Golgi associated kinase 1B; Belongs to the GASK family. | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50. | 0.513 |
| GASK1B | DIAPH2 | ENSP00000377396 | ENSP00000321348 | Golgi associated kinase 1B; Belongs to the GASK family. | Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton; Belongs to the formin homology family. Diaphanous subfamily. | 0.464 |
| GASK1B | FAM20A | ENSP00000377396 | ENSP00000468308 | Golgi associated kinase 1B; Belongs to the GASK family. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.476 |
| GASK1B | FAM20B | ENSP00000377396 | ENSP00000263733 | Golgi associated kinase 1B; Belongs to the GASK family. | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalyti [...] | 0.442 |
| GASK1B | GLRB | ENSP00000377396 | ENSP00000264428 | Golgi associated kinase 1B; Belongs to the GASK family. | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. | 0.480 |
| GASK1B | MRVI1 | ENSP00000377396 | ENSP00000412130 | Golgi associated kinase 1B; Belongs to the GASK family. | Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. | 0.430 |
| GASK1B | TMTC3 | ENSP00000377396 | ENSP00000266712 | Golgi associated kinase 1B; Belongs to the GASK family. | Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. | 0.434 |
| GASK1B | TSPAN19 | ENSP00000377396 | ENSP00000433816 | Golgi associated kinase 1B; Belongs to the GASK family. | Putative tetraspanin-19; Tetraspanin 19. | 0.470 |
