node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTG1 | ENSP00000494750 | ENSP00000458162 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.999 |
ACTB | ANXA4 | ENSP00000494750 | ENSP00000377833 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.596 |
ACTB | ANXA6 | ENSP00000494750 | ENSP00000346550 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | 0.444 |
ACTB | CCR5 | ENSP00000494750 | ENSP00000292303 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. | 0.431 |
ACTG1 | ACTB | ENSP00000458162 | ENSP00000494750 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.999 |
ACTG1 | ANXA4 | ENSP00000458162 | ENSP00000377833 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.686 |
ACTG1 | S100A10 | ENSP00000458162 | ENSP00000357801 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.486 |
ANXA4 | ACTB | ENSP00000377833 | ENSP00000494750 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.596 |
ANXA4 | ACTG1 | ENSP00000377833 | ENSP00000458162 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.686 |
ANXA4 | ANXA6 | ENSP00000377833 | ENSP00000346550 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | 0.694 |
ANXA4 | CCR5 | ENSP00000377833 | ENSP00000292303 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. | 0.793 |
ANXA4 | CD248 | ENSP00000377833 | ENSP00000308117 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Endosialin; May play a role in tumor angiogenesis. | 0.573 |
ANXA4 | F3 | ENSP00000377833 | ENSP00000334145 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.606 |
ANXA4 | PADI4 | ENSP00000377833 | ENSP00000364597 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Protein-arginine deiminase type-4; Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displaceme [...] | 0.591 |
ANXA4 | RBP2 | ENSP00000377833 | ENSP00000232217 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Retinol-binding protein 2; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.542 |
ANXA4 | S100A10 | ENSP00000377833 | ENSP00000357801 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.802 |
ANXA4 | S100A6 | ENSP00000377833 | ENSP00000357709 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | 0.579 |
ANXA6 | ACTB | ENSP00000346550 | ENSP00000494750 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.444 |
ANXA6 | ANXA4 | ENSP00000346550 | ENSP00000377833 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.694 |
ANXA6 | S100A10 | ENSP00000346550 | ENSP00000357801 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.464 |