ZBTB9 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXD4	FOXD4L1	ENSP00000371940	ENSP00000302756	Forkhead box D4.	Forkhead box D4 like 1.	0.997
FOXD4	FOXD4L6	ENSP00000371940	ENSP00000484875	Forkhead box D4.	Forkhead box D4 like 6.	0.941
FOXD4	ZBTB9	ENSP00000371940	ENSP00000378503	Forkhead box D4.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.547
FOXD4L1	FOXD4	ENSP00000302756	ENSP00000371940	Forkhead box D4 like 1.	Forkhead box D4.	0.997
FOXD4L1	FOXD4L6	ENSP00000302756	ENSP00000484875	Forkhead box D4 like 1.	Forkhead box D4 like 6.	0.942
FOXD4L1	ZBTB9	ENSP00000302756	ENSP00000378503	Forkhead box D4 like 1.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.774
FOXD4L6	FOXD4	ENSP00000484875	ENSP00000371940	Forkhead box D4 like 6.	Forkhead box D4.	0.941
FOXD4L6	FOXD4L1	ENSP00000484875	ENSP00000302756	Forkhead box D4 like 6.	Forkhead box D4 like 1.	0.942
FOXD4L6	ZBTB9	ENSP00000484875	ENSP00000378503	Forkhead box D4 like 6.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.596
KRTAP10-7	ZBTB9	ENSP00000476821	ENSP00000378503	Keratin-associated protein 10-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.531
LASP1	ZBTB9	ENSP00000325240	ENSP00000378503	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.542
MED29	ZBTB9	ENSP00000481733	ENSP00000378503	Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.580
PIN4	ZBTB9	ENSP00000499466	ENSP00000378503	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double- stranded DNA.	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.521
PSME3	TP53BP1	ENSP00000293362	ENSP00000371475	Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...]	TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs s [...]	0.766
PSME3	ZBTB9	ENSP00000293362	ENSP00000378503	Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...]	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.526
TP53BP1	PSME3	ENSP00000371475	ENSP00000293362	TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs s [...]	Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...]	0.766
TP53BP1	ZBTB9	ENSP00000371475	ENSP00000378503	TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs s [...]	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	0.751
ZBTB9	FOXD4	ENSP00000378503	ENSP00000371940	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	Forkhead box D4.	0.547
ZBTB9	FOXD4L1	ENSP00000378503	ENSP00000302756	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	Forkhead box D4 like 1.	0.774
ZBTB9	FOXD4L6	ENSP00000378503	ENSP00000484875	Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.	Forkhead box D4 like 6.	0.596