node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf116 | CFAP53 | ENSP00000395281 | ENSP00000381553 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | 0.882 |
C9orf116 | EFHB | ENSP00000395281 | ENSP00000295824 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | 0.835 |
C9orf116 | EFHC1 | ENSP00000395281 | ENSP00000360107 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. | 0.854 |
C9orf116 | ENKUR | ENSP00000395281 | ENSP00000331044 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. | 0.828 |
C9orf116 | RIBC2 | ENSP00000395281 | ENSP00000483356 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | RIB43A domain with coiled-coils 2. | 0.846 |
C9orf116 | SPAG8 | ENSP00000395281 | ENSP00000340982 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. | 0.831 |
C9orf116 | TEKT1 | ENSP00000395281 | ENSP00000341346 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. | 0.942 |
C9orf116 | TEKT2 | ENSP00000395281 | ENSP00000207457 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. | 0.849 |
C9orf116 | TEKT3 | ENSP00000395281 | ENSP00000379263 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | 0.862 |
C9orf116 | TUBB4B | ENSP00000395281 | ENSP00000341289 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. | 0.830 |
CFAP53 | C9orf116 | ENSP00000381553 | ENSP00000395281 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. | 0.882 |
CFAP53 | EFHB | ENSP00000381553 | ENSP00000295824 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | 0.848 |
CFAP53 | EFHC1 | ENSP00000381553 | ENSP00000360107 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. | 0.835 |
CFAP53 | ENKUR | ENSP00000381553 | ENSP00000331044 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. | 0.842 |
CFAP53 | RIBC2 | ENSP00000381553 | ENSP00000483356 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | RIB43A domain with coiled-coils 2. | 0.830 |
CFAP53 | SPAG8 | ENSP00000381553 | ENSP00000340982 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. | 0.859 |
CFAP53 | TEKT1 | ENSP00000381553 | ENSP00000341346 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. | 0.849 |
CFAP53 | TEKT2 | ENSP00000381553 | ENSP00000207457 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. | 0.888 |
CFAP53 | TEKT3 | ENSP00000381553 | ENSP00000379263 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. | 0.885 |
CFAP53 | TUBB4B | ENSP00000381553 | ENSP00000341289 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. | Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. | 0.852 |