node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG1L | DQX1 | ENSP00000482705 | ENSP00000384621 | Putative glycosyltransferase ALG1-like; Putative glycosyltransferase. | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1. | 0.431 |
ALG1L | ZNF418 | ENSP00000482705 | ENSP00000407039 | Putative glycosyltransferase ALG1-like; Putative glycosyltransferase. | Zinc finger protein 418; Transcriptional repressor. | 0.531 |
CCDC115 | TMEM211 | ENSP00000259229 | ENSP00000385494 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. | Transmembrane protein 211. | 0.483 |
CCDC115 | ZNF418 | ENSP00000259229 | ENSP00000407039 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. | Zinc finger protein 418; Transcriptional repressor. | 0.488 |
DQX1 | ALG1L | ENSP00000384621 | ENSP00000482705 | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1. | Putative glycosyltransferase ALG1-like; Putative glycosyltransferase. | 0.431 |
DQX1 | ZNF418 | ENSP00000384621 | ENSP00000407039 | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1. | Zinc finger protein 418; Transcriptional repressor. | 0.456 |
TGM4 | ZNF418 | ENSP00000296125 | ENSP00000407039 | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract. | Zinc finger protein 418; Transcriptional repressor. | 0.428 |
TMEM211 | CCDC115 | ENSP00000385494 | ENSP00000259229 | Transmembrane protein 211. | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. | 0.483 |
TMEM211 | ZNF418 | ENSP00000385494 | ENSP00000407039 | Transmembrane protein 211. | Zinc finger protein 418; Transcriptional repressor. | 0.557 |
TRIM28 | ZNF267 | ENSP00000253024 | ENSP00000300870 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 267; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.724 |
TRIM28 | ZNF418 | ENSP00000253024 | ENSP00000407039 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 418; Transcriptional repressor. | 0.587 |
VILL | ZNF418 | ENSP00000283713 | ENSP00000407039 | Villin-like protein; Possible tumor suppressor. | Zinc finger protein 418; Transcriptional repressor. | 0.616 |
ZNF267 | TRIM28 | ENSP00000300870 | ENSP00000253024 | Zinc finger protein 267; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.724 |
ZNF267 | ZNF418 | ENSP00000300870 | ENSP00000407039 | Zinc finger protein 267; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 418; Transcriptional repressor. | 0.609 |
ZNF418 | ALG1L | ENSP00000407039 | ENSP00000482705 | Zinc finger protein 418; Transcriptional repressor. | Putative glycosyltransferase ALG1-like; Putative glycosyltransferase. | 0.531 |
ZNF418 | CCDC115 | ENSP00000407039 | ENSP00000259229 | Zinc finger protein 418; Transcriptional repressor. | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis. | 0.488 |
ZNF418 | DQX1 | ENSP00000407039 | ENSP00000384621 | Zinc finger protein 418; Transcriptional repressor. | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1. | 0.456 |
ZNF418 | TGM4 | ENSP00000407039 | ENSP00000296125 | Zinc finger protein 418; Transcriptional repressor. | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract. | 0.428 |
ZNF418 | TMEM211 | ENSP00000407039 | ENSP00000385494 | Zinc finger protein 418; Transcriptional repressor. | Transmembrane protein 211. | 0.557 |
ZNF418 | TRIM28 | ENSP00000407039 | ENSP00000253024 | Zinc finger protein 418; Transcriptional repressor. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.587 |