TMC5 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMC1	TMC5	ENSP00000418348	ENSP00000379531	COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.	Transmembrane channel-like protein 5; Probable ion channel.	0.496
CMC1	ZFC3H1	ENSP00000418348	ENSP00000368017	COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.	Zinc finger C3H1 domain-containing protein; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.	0.490
KCNH8	TMC5	ENSP00000328813	ENSP00000379531	Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.	Transmembrane channel-like protein 5; Probable ion channel.	0.472
RNF175	TMC5	ENSP00000340979	ENSP00000379531	Ring finger protein 175.	Transmembrane channel-like protein 5; Probable ion channel.	0.435
RNF175	WSCD1	ENSP00000340979	ENSP00000460825	Ring finger protein 175.	WSC domain containing 1.	0.470
TMC5	CMC1	ENSP00000379531	ENSP00000418348	Transmembrane channel-like protein 5; Probable ion channel.	COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.	0.496
TMC5	KCNH8	ENSP00000379531	ENSP00000328813	Transmembrane channel-like protein 5; Probable ion channel.	Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.	0.472
TMC5	RNF175	ENSP00000379531	ENSP00000340979	Transmembrane channel-like protein 5; Probable ion channel.	Ring finger protein 175.	0.435
TMC5	TMEM132E	ENSP00000379531	ENSP00000487800	Transmembrane channel-like protein 5; Probable ion channel.	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.	0.527
TMC5	TMEM171	ENSP00000379531	ENSP00000415030	Transmembrane channel-like protein 5; Probable ion channel.	Transmembrane protein 171.	0.432
TMC5	TMEM211	ENSP00000379531	ENSP00000385494	Transmembrane channel-like protein 5; Probable ion channel.	Transmembrane protein 211.	0.458
TMC5	TMEM221	ENSP00000379531	ENSP00000342162	Transmembrane channel-like protein 5; Probable ion channel.	Transmembrane protein 221.	0.468
TMC5	UNC119	ENSP00000379531	ENSP00000337040	Transmembrane channel-like protein 5; Probable ion channel.	Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...]	0.462
TMC5	WSCD1	ENSP00000379531	ENSP00000460825	Transmembrane channel-like protein 5; Probable ion channel.	WSC domain containing 1.	0.437
TMC5	ZFC3H1	ENSP00000379531	ENSP00000368017	Transmembrane channel-like protein 5; Probable ion channel.	Zinc finger C3H1 domain-containing protein; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.	0.448
TMEM132E	TMC5	ENSP00000487800	ENSP00000379531	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.	Transmembrane channel-like protein 5; Probable ion channel.	0.527
TMEM132E	TMEM171	ENSP00000487800	ENSP00000415030	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.	Transmembrane protein 171.	0.549
TMEM132E	TMEM211	ENSP00000487800	ENSP00000385494	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.	Transmembrane protein 211.	0.508
TMEM132E	TMEM221	ENSP00000487800	ENSP00000342162	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.	Transmembrane protein 221.	0.653
TMEM171	TMC5	ENSP00000415030	ENSP00000379531	Transmembrane protein 171.	Transmembrane channel-like protein 5; Probable ion channel.	0.432