Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPLX1 | CPLX3 | ENSP00000305613 | ENSP00000378464 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | 0.968 |
| CPLX1 | CPLX4 | ENSP00000305613 | ENSP00000299721 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Complexin-3/4; Complexin-4; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | 0.936 |
| CPLX1 | SNAP23 | ENSP00000305613 | ENSP00000249647 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.832 |
| CPLX1 | SNAP25 | ENSP00000305613 | ENSP00000254976 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.999 |
| CPLX1 | STX1A | ENSP00000305613 | ENSP00000222812 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.999 |
| CPLX1 | STX1B | ENSP00000305613 | ENSP00000215095 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity); Belongs to the syntaxin family | 0.902 |
| CPLX1 | STX2 | ENSP00000305613 | ENSP00000376178 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.712 |
| CPLX1 | STX3 | ENSP00000305613 | ENSP00000338562 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family | 0.802 |
| CPLX1 | STX4 | ENSP00000305613 | ENSP00000317714 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family | 0.851 |
| CPLX1 | VAMP1 | ENSP00000305613 | ENSP00000379602 | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.881 |
| CPLX3 | CPLX1 | ENSP00000378464 | ENSP00000305613 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Complexin-1/2; Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior | 0.968 |
| CPLX3 | CPLX4 | ENSP00000378464 | ENSP00000299721 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Complexin-3/4; Complexin-4; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | 0.807 |
| CPLX3 | SNAP23 | ENSP00000378464 | ENSP00000249647 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.641 |
| CPLX3 | SNAP25 | ENSP00000378464 | ENSP00000254976 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.934 |
| CPLX3 | STX1A | ENSP00000378464 | ENSP00000222812 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.927 |
| CPLX3 | STX1B | ENSP00000378464 | ENSP00000215095 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity); Belongs to the syntaxin family | 0.756 |
| CPLX3 | STX2 | ENSP00000378464 | ENSP00000376178 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.610 |
| CPLX3 | STX3 | ENSP00000378464 | ENSP00000338562 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family | 0.854 |
| CPLX3 | STX4 | ENSP00000378464 | ENSP00000317714 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family | 0.633 |
| CPLX3 | VAMP1 | ENSP00000378464 | ENSP00000379602 | Complexin-3/4; Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.934 |
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