CLDN6 protein (human) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

CLDN6

Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins (220 aa)

Predicted Functional Partners:

TJP1

0.901

OCLN

0.847

TJP3

0.811

ESAM

0.776

CLDN12

0.730

CLDN23

0.698

CLDN34

0.684

CLDN16

0.674

CLDN11

0.673

PARD3

0.672

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN11	CLDN12	ENSP00000064724	ENSP00000287916	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.741
CLDN11	CLDN16	ENSP00000064724	ENSP00000264734	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins	0.679
CLDN11	CLDN23	ENSP00000064724	ENSP00000428780	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.843
CLDN11	CLDN34	ENSP00000064724	ENSP00000403980	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin 34; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity	0.614
CLDN11	CLDN6	ENSP00000064724	ENSP00000380131	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins	0.673
CLDN11	ESAM	ENSP00000064724	ENSP00000278927	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily	0.669
CLDN11	OCLN	ENSP00000064724	ENSP00000347379	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions; Protein phosphatase 1 regulatory subunits	0.895
CLDN11	PARD3	ENSP00000064724	ENSP00000363921	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of [...]	0.610
CLDN11	TJP1	ENSP00000064724	ENSP00000281537	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Tight junction protein ZO-1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells; Belongs to the MAGUK family	0.892
CLDN11	TJP3	ENSP00000064724	ENSP00000465419	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Tight junction protein ZO-3; Membrane associated guanylate kinases	0.792
CLDN12	CLDN11	ENSP00000287916	ENSP00000064724	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.741
CLDN12	CLDN16	ENSP00000287916	ENSP00000264734	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins	0.732
CLDN12	CLDN23	ENSP00000287916	ENSP00000428780	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.630
CLDN12	CLDN6	ENSP00000287916	ENSP00000380131	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins	0.730
CLDN12	OCLN	ENSP00000287916	ENSP00000347379	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions; Protein phosphatase 1 regulatory subunits	0.741
CLDN12	TJP1	ENSP00000287916	ENSP00000281537	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Tight junction protein ZO-1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells; Belongs to the MAGUK family	0.847
CLDN12	TJP3	ENSP00000287916	ENSP00000465419	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Tight junction protein ZO-3; Membrane associated guanylate kinases	0.586
CLDN16	CLDN11	ENSP00000264734	ENSP00000064724	Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins	Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.679
CLDN16	CLDN12	ENSP00000264734	ENSP00000287916	Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.732
CLDN16	CLDN23	ENSP00000264734	ENSP00000428780	Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins	Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.905