FLYWCH2 protein (human) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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Score

FLYWCH2

FLYWCH family member 2. (140 aa)

Predicted Functional Partners:

HSPA8

0.612

TBC1D23

0.605

HCFC1R1

0.517

THEM6

0.508

RXRB

0.506

BICDL2

0.486

ZNF720

0.473

FAM86C1

0.448

TMEM235

0.447

THOC6

0.445

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BICDL2	FLYWCH2	ENSP00000459043	ENSP00000380159	BICD family like cargo adaptor 2.	FLYWCH family member 2.	0.486
BICDL2	HCFC1R1	ENSP00000459043	ENSP00000248089	BICD family like cargo adaptor 2.	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	0.455
BICDL2	TMEM235	ENSP00000459043	ENSP00000402790	BICD family like cargo adaptor 2.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.432
FAM86C1	FLYWCH2	ENSP00000352182	ENSP00000380159	Protein FAM86C1.	FLYWCH family member 2.	0.448
FAM86C1	ZNF720	ENSP00000352182	ENSP00000319222	Protein FAM86C1.	Putative protein ZNF720; Zinc finger protein 720.	0.479
FLYWCH2	BICDL2	ENSP00000380159	ENSP00000459043	FLYWCH family member 2.	BICD family like cargo adaptor 2.	0.486
FLYWCH2	FAM86C1	ENSP00000380159	ENSP00000352182	FLYWCH family member 2.	Protein FAM86C1.	0.448
FLYWCH2	HCFC1R1	ENSP00000380159	ENSP00000248089	FLYWCH family member 2.	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	0.517
FLYWCH2	HSPA8	ENSP00000380159	ENSP00000437125	FLYWCH family member 2.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.612
FLYWCH2	RXRB	ENSP00000380159	ENSP00000363817	FLYWCH family member 2.	Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily.	0.506
FLYWCH2	TBC1D23	ENSP00000380159	ENSP00000377700	FLYWCH family member 2.	TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly [...]	0.605
FLYWCH2	THEM6	ENSP00000380159	ENSP00000338607	FLYWCH family member 2.	Protein THEM6; Thioesterase superfamily member 6.	0.508
FLYWCH2	THOC6	ENSP00000380159	ENSP00000326531	FLYWCH family member 2.	THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essentia [...]	0.445
FLYWCH2	TMEM235	ENSP00000380159	ENSP00000402790	FLYWCH family member 2.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.447
FLYWCH2	ZNF720	ENSP00000380159	ENSP00000319222	FLYWCH family member 2.	Putative protein ZNF720; Zinc finger protein 720.	0.473
HCFC1R1	BICDL2	ENSP00000248089	ENSP00000459043	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	BICD family like cargo adaptor 2.	0.455
HCFC1R1	FLYWCH2	ENSP00000248089	ENSP00000380159	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	FLYWCH family member 2.	0.517
HCFC1R1	THOC6	ENSP00000248089	ENSP00000326531	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essentia [...]	0.534
HCFC1R1	TMEM235	ENSP00000248089	ENSP00000402790	Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.418
HSPA8	FLYWCH2	ENSP00000437125	ENSP00000380159	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	FLYWCH family member 2.	0.612