node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR107 | GPR146 | ENSP00000361483 | ENSP00000380283 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.665 |
GPR139 | GPR146 | ENSP00000458791 | ENSP00000380283 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.619 |
GPR139 | GPR148 | ENSP00000458791 | ENSP00000308908 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Probable G-protein coupled receptor 148; Orphan receptor. | 0.476 |
GPR139 | GPR153 | ENSP00000458791 | ENSP00000367125 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.473 |
GPR139 | GPR162 | ENSP00000458791 | ENSP00000311528 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Probable G-protein coupled receptor 162; Orphan receptor. | 0.518 |
GPR139 | NMU | ENSP00000458791 | ENSP00000264218 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Neuromedin precursor-related peptide 33; [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. | 0.468 |
GPR139 | TRH | ENSP00000458791 | ENSP00000303452 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Pro-thyrotropin-releasing hormone; As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. | 0.479 |
GPR142 | GPR146 | ENSP00000335158 | ENSP00000380283 | Probable G-protein coupled receptor 142; Orphan receptor. | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.453 |
GPR142 | GPR148 | ENSP00000335158 | ENSP00000308908 | Probable G-protein coupled receptor 142; Orphan receptor. | Probable G-protein coupled receptor 148; Orphan receptor. | 0.450 |
GPR142 | GPR162 | ENSP00000335158 | ENSP00000311528 | Probable G-protein coupled receptor 142; Orphan receptor. | Probable G-protein coupled receptor 162; Orphan receptor. | 0.411 |
GPR142 | GPR82 | ENSP00000335158 | ENSP00000303549 | Probable G-protein coupled receptor 142; Orphan receptor. | Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.527 |
GPR142 | NMU | ENSP00000335158 | ENSP00000264218 | Probable G-protein coupled receptor 142; Orphan receptor. | Neuromedin precursor-related peptide 33; [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. | 0.430 |
GPR142 | TRH | ENSP00000335158 | ENSP00000303452 | Probable G-protein coupled receptor 142; Orphan receptor. | Pro-thyrotropin-releasing hormone; As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. | 0.462 |
GPR146 | GPR107 | ENSP00000380283 | ENSP00000361483 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.665 |
GPR146 | GPR139 | ENSP00000380283 | ENSP00000458791 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.619 |
GPR146 | GPR142 | ENSP00000380283 | ENSP00000335158 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 142; Orphan receptor. | 0.453 |
GPR146 | GPR148 | ENSP00000380283 | ENSP00000308908 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 148; Orphan receptor. | 0.438 |
GPR146 | GPR153 | ENSP00000380283 | ENSP00000367125 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.479 |
GPR146 | GPR162 | ENSP00000380283 | ENSP00000311528 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 162; Orphan receptor. | 0.539 |
GPR146 | GPR82 | ENSP00000380283 | ENSP00000303549 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.445 |