node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C7orf50 | DKC1 | ENSP00000380286 | ENSP00000358563 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | 0.638 |
C7orf50 | DNTTIP2 | ENSP00000380286 | ENSP00000411010 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. | 0.652 |
C7orf50 | EBNA1BP2 | ENSP00000380286 | ENSP00000407323 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.618 |
C7orf50 | MAK16 | ENSP00000380286 | ENSP00000353246 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | MAK16 homolog. | 0.662 |
C7orf50 | NIFK | ENSP00000380286 | ENSP00000285814 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.569 |
C7orf50 | NOP53 | ENSP00000380286 | ENSP00000246802 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...] | 0.566 |
C7orf50 | PUM3 | ENSP00000380286 | ENSP00000380982 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity). | 0.648 |
C7orf50 | RRP15 | ENSP00000380286 | ENSP00000355899 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | RRP15-like protein; Ribosomal RNA processing 15 homolog. | 0.597 |
C7orf50 | SURF6 | ENSP00000380286 | ENSP00000361092 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). | 0.751 |
C7orf50 | TMA16 | ENSP00000380286 | ENSP00000351380 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | Translation machinery associated 16 homolog. | 0.635 |
DKC1 | C7orf50 | ENSP00000358563 | ENSP00000380286 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | 0.638 |
DKC1 | EBNA1BP2 | ENSP00000358563 | ENSP00000407323 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.888 |
DKC1 | MAK16 | ENSP00000358563 | ENSP00000353246 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | MAK16 homolog. | 0.567 |
DKC1 | NIFK | ENSP00000358563 | ENSP00000285814 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Nucleolar protein interacting with the FHA domain of MKI67. | 0.959 |
DKC1 | NOP53 | ENSP00000358563 | ENSP00000246802 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...] | 0.906 |
DKC1 | PUM3 | ENSP00000358563 | ENSP00000380982 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity). | 0.928 |
DKC1 | RRP15 | ENSP00000358563 | ENSP00000355899 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | RRP15-like protein; Ribosomal RNA processing 15 homolog. | 0.416 |
DKC1 | SURF6 | ENSP00000358563 | ENSP00000361092 | H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...] | Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). | 0.594 |
DNTTIP2 | C7orf50 | ENSP00000411010 | ENSP00000380286 | Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. | 0.652 |
DNTTIP2 | EBNA1BP2 | ENSP00000411010 | ENSP00000407323 | Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.846 |