CRAMP1 protein (human) - STRING interaction network

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[Homology]

Score

CRAMP1

Protein cramped-like; Cramped chromatin regulator homolog 1. (1269 aa)

Predicted Functional Partners:

GON4L

0.995

SS18L2

0.953

NPAT

0.944

PPP4R3B

0.841

PPP4R2

0.812

PPP4R3A

0.758

SDR42E2

0.619

H2BC1

0.582

LBHD1

0.564

JPT2

0.524

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRAMP1	GON4L	ENSP00000380559	ENSP00000357315	Protein cramped-like; Cramped chromatin regulator homolog 1.	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	0.995
CRAMP1	H2BC1	ENSP00000380559	ENSP00000274764	Protein cramped-like; Cramped chromatin regulator homolog 1.	Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By [...]	0.582
CRAMP1	JPT2	ENSP00000380559	ENSP00000248098	Protein cramped-like; Cramped chromatin regulator homolog 1.	Jupiter microtubule associated homolog 2; Belongs to the JUPITER family.	0.524
CRAMP1	LBHD1	ENSP00000380559	ENSP00000436848	Protein cramped-like; Cramped chromatin regulator homolog 1.	LBH domain containing 1.	0.564
CRAMP1	NPAT	ENSP00000380559	ENSP00000278612	Protein cramped-like; Cramped chromatin regulator homolog 1.	Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Belongs to the NPAT family.	0.944
CRAMP1	PPP4R2	ENSP00000380559	ENSP00000349124	Protein cramped-like; Cramped chromatin regulator homolog 1.	Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylatio [...]	0.812
CRAMP1	PPP4R3A	ENSP00000380559	ENSP00000450864	Protein cramped-like; Cramped chromatin regulator homolog 1.	Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family.	0.758
CRAMP1	PPP4R3B	ENSP00000380559	ENSP00000483228	Protein cramped-like; Cramped chromatin regulator homolog 1.	Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family.	0.841
CRAMP1	SDR42E2	ENSP00000380559	ENSP00000473474	Protein cramped-like; Cramped chromatin regulator homolog 1.	Short chain dehydrogenase/reductase family 42E, member 2; Belongs to the 3-beta-HSD family.	0.619
CRAMP1	SS18L2	ENSP00000380559	ENSP00000401115	Protein cramped-like; Cramped chromatin regulator homolog 1.	SS18-like protein 2; SS18 like 2.	0.953
GON4L	CRAMP1	ENSP00000357315	ENSP00000380559	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	Protein cramped-like; Cramped chromatin regulator homolog 1.	0.995
GON4L	H2BC1	ENSP00000357315	ENSP00000274764	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By [...]	0.604
GON4L	NPAT	ENSP00000357315	ENSP00000278612	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Belongs to the NPAT family.	0.485
GON4L	SS18L2	ENSP00000357315	ENSP00000401115	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	SS18-like protein 2; SS18 like 2.	0.985
H2BC1	CRAMP1	ENSP00000274764	ENSP00000380559	Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By [...]	Protein cramped-like; Cramped chromatin regulator homolog 1.	0.582
H2BC1	GON4L	ENSP00000274764	ENSP00000357315	Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By [...]	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	0.604
JPT2	CRAMP1	ENSP00000248098	ENSP00000380559	Jupiter microtubule associated homolog 2; Belongs to the JUPITER family.	Protein cramped-like; Cramped chromatin regulator homolog 1.	0.524
LBHD1	CRAMP1	ENSP00000436848	ENSP00000380559	LBH domain containing 1.	Protein cramped-like; Cramped chromatin regulator homolog 1.	0.564
NPAT	CRAMP1	ENSP00000278612	ENSP00000380559	Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Belongs to the NPAT family.	Protein cramped-like; Cramped chromatin regulator homolog 1.	0.944
NPAT	GON4L	ENSP00000278612	ENSP00000357315	Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Belongs to the NPAT family.	GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	0.485