node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPIFA1 | BPIFC | ENSP00000346251 | ENSP00000380594 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI fold containing family C. | 0.422 |
BPIFC | BPIFA1 | ENSP00000380594 | ENSP00000346251 | BPI fold containing family C. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.422 |
BPIFC | CALHM4 | ENSP00000380594 | ENSP00000385836 | BPI fold containing family C. | Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel. | 0.408 |
BPIFC | DEFB115 | ENSP00000380594 | ENSP00000383398 | BPI fold containing family C. | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | 0.492 |
BPIFC | DEFB128 | ENSP00000380594 | ENSP00000335382 | BPI fold containing family C. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.470 |
BPIFC | FLG2 | ENSP00000380594 | ENSP00000373370 | BPI fold containing family C. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | 0.425 |
BPIFC | IQCD | ENSP00000380594 | ENSP00000400669 | BPI fold containing family C. | Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family. | 0.478 |
BPIFC | PGLYRP3 | ENSP00000380594 | ENSP00000290722 | BPI fold containing family C. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.456 |
BPIFC | TMEM239 | ENSP00000380594 | ENSP00000354312 | BPI fold containing family C. | Transmembrane protein 239. | 0.590 |
BPIFC | WFDC12 | ENSP00000380594 | ENSP00000361871 | BPI fold containing family C. | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. | 0.587 |
CALHM4 | BPIFC | ENSP00000385836 | ENSP00000380594 | Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel. | BPI fold containing family C. | 0.408 |
DEFB115 | BPIFC | ENSP00000383398 | ENSP00000380594 | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | BPI fold containing family C. | 0.492 |
DEFB115 | DEFB128 | ENSP00000383398 | ENSP00000335382 | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.731 |
DEFB115 | PGLYRP3 | ENSP00000383398 | ENSP00000290722 | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.445 |
DEFB115 | WFDC12 | ENSP00000383398 | ENSP00000361871 | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. | 0.477 |
DEFB128 | BPIFC | ENSP00000335382 | ENSP00000380594 | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | BPI fold containing family C. | 0.470 |
DEFB128 | DEFB115 | ENSP00000335382 | ENSP00000383398 | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | 0.731 |
DEFB128 | WFDC12 | ENSP00000335382 | ENSP00000361871 | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. | 0.440 |
FLG2 | BPIFC | ENSP00000373370 | ENSP00000380594 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | BPI fold containing family C. | 0.425 |
IQCD | BPIFC | ENSP00000400669 | ENSP00000380594 | Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family. | BPI fold containing family C. | 0.478 |