STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG7Pleckstrin homology and RhoGEF domain containing G7. (379 aa)    
Predicted Functional Partners:
TMEM213
Transmembrane protein 213.
   
  
 0.484
ZNF485
Zinc finger protein 485; May be involved in transcriptional regulation.
      
 0.475
FER1L6
Fer-1-like protein 6; Fer-1 like family member 6.
   
  
 0.470
EFCAB1
EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1.
   
  
 0.467
ARHGEF33
Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor.
    
 
 0.464
ARHGEF38
Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor.
   
  
 0.457
KBTBD12
Kelch repeat and BTB domain containing 12.
   
  
 0.448
RIMS2
Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
      
 0.435
ZNF483
Zinc finger protein 483; May be involved in transcriptional regulation.
   
  
 0.432
WDFY3
WD repeat and FYVE domain-containing protein 3; Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5- ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain developmen [...]
      
 0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.