| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPZB | KIAA1211L | ENSP00000401010 | ENSP00000380996 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | Uncharacterized protein KIAA1211-like. | 0.473 |
| CAPZB | PRC1 | ENSP00000401010 | ENSP00000377793 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] | 0.466 |
| CAPZB | RLIM | ENSP00000401010 | ENSP00000328059 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.457 |
| CWH43 | KIAA1211L | ENSP00000226432 | ENSP00000380996 | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. | Uncharacterized protein KIAA1211-like. | 0.513 |
| GIMAP6 | KIAA1211L | ENSP00000479580 | ENSP00000380996 | GTPase, IMAP family member 6. | Uncharacterized protein KIAA1211-like. | 0.512 |
| KIAA1211L | CAPZB | ENSP00000380996 | ENSP00000401010 | Uncharacterized protein KIAA1211-like. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.473 |
| KIAA1211L | CWH43 | ENSP00000380996 | ENSP00000226432 | Uncharacterized protein KIAA1211-like. | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. | 0.513 |
| KIAA1211L | GIMAP6 | ENSP00000380996 | ENSP00000479580 | Uncharacterized protein KIAA1211-like. | GTPase, IMAP family member 6. | 0.512 |
| KIAA1211L | KLRG2 | ENSP00000380996 | ENSP00000339356 | Uncharacterized protein KIAA1211-like. | Killer cell lectin like receptor G2. | 0.400 |
| KIAA1211L | MEGF9 | ENSP00000380996 | ENSP00000363040 | Uncharacterized protein KIAA1211-like. | Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9. | 0.406 |
| KIAA1211L | PDE2A | ENSP00000380996 | ENSP00000334910 | Uncharacterized protein KIAA1211-like. | cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line). | 0.421 |
| KIAA1211L | PRC1 | ENSP00000380996 | ENSP00000377793 | Uncharacterized protein KIAA1211-like. | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] | 0.464 |
| KIAA1211L | RLIM | ENSP00000380996 | ENSP00000328059 | Uncharacterized protein KIAA1211-like. | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.457 |
| KLRG2 | KIAA1211L | ENSP00000339356 | ENSP00000380996 | Killer cell lectin like receptor G2. | Uncharacterized protein KIAA1211-like. | 0.400 |
| MEGF9 | KIAA1211L | ENSP00000363040 | ENSP00000380996 | Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9. | Uncharacterized protein KIAA1211-like. | 0.406 |
| PDE2A | KIAA1211L | ENSP00000334910 | ENSP00000380996 | cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line). | Uncharacterized protein KIAA1211-like. | 0.421 |
| PRC1 | CAPZB | ENSP00000377793 | ENSP00000401010 | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.466 |
| PRC1 | KIAA1211L | ENSP00000377793 | ENSP00000380996 | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] | Uncharacterized protein KIAA1211-like. | 0.464 |
| RLIM | CAPZB | ENSP00000328059 | ENSP00000401010 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.457 |
| RLIM | KIAA1211L | ENSP00000328059 | ENSP00000380996 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | Uncharacterized protein KIAA1211-like. | 0.457 |
