STRINGSTRING
MUC16 protein (human) - STRING interaction network
"MUC16" - Mucin 16, cell surface associated in Homo sapiens
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MUC16Mucin 16, cell surface associated; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (14507 aa)    
Predicted Functional Partners:
MUC4
Mucin 4, cell surface associated; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of [...] (5412 aa)
         
  0.977
MUC17
Mucin 17, cell surface associated; Probably plays a role in maintaining homeostasis on mucosal surfaces (4493 aa)
         
  0.971
MUC12
Mucin 12, cell surface associated; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium (5335 aa)
         
  0.970
MUC1
Mucin 1, cell surface associated; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack (475 aa)
         
  0.969
MUC5AC
Mucin 5AC, oligomeric mucus/gel-forming; Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system (623 aa)
     
 
  0.963
MUC6
Mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis (2439 aa)
     
 
  0.963
MUC13
Mucin 13, cell surface associated; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling (511 aa)
         
  0.963
MUC20
Mucin 20, cell surface associated; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (723 aa)
         
  0.961
MUC3A
Mucin 3A, cell surface associated; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling (876 aa)
         
  0.961
MUC15
Mucin 15, cell surface associated; May play a role in the cell adhesion to the extracellular matrix (361 aa)
         
  0.961
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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