node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf40 | SLC35E3 | ENSP00000403987 | ENSP00000381089 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.779 |
CDK10 | SLC35E3 | ENSP00000338673 | ENSP00000381089 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.538 |
MDM2 | NUP107 | ENSP00000258149 | ENSP00000229179 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | 0.482 |
MDM2 | SLC35E3 | ENSP00000258149 | ENSP00000381089 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.732 |
NUP107 | MDM2 | ENSP00000229179 | ENSP00000258149 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | 0.482 |
NUP107 | SLC35E3 | ENSP00000229179 | ENSP00000381089 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.750 |
RNF217 | SLC35E3 | ENSP00000428698 | ENSP00000381089 | Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RBR family. RNF217 subfamily. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.486 |
SLC35C1 | SLC35C2 | ENSP00000313318 | ENSP00000318960 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | 0.804 |
SLC35C1 | SLC35D1 | ENSP00000313318 | ENSP00000235345 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | 0.579 |
SLC35C1 | SLC35E3 | ENSP00000313318 | ENSP00000381089 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.527 |
SLC35C1 | SLC35G1 | ENSP00000313318 | ENSP00000400932 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. | 0.520 |
SLC35C2 | SLC35C1 | ENSP00000318960 | ENSP00000313318 | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | 0.804 |
SLC35C2 | SLC35D1 | ENSP00000318960 | ENSP00000235345 | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | 0.662 |
SLC35C2 | SLC35E3 | ENSP00000318960 | ENSP00000381089 | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.580 |
SLC35C2 | SLC35G1 | ENSP00000318960 | ENSP00000400932 | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. | 0.470 |
SLC35D1 | SLC35C1 | ENSP00000235345 | ENSP00000313318 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. | 0.579 |
SLC35D1 | SLC35C2 | ENSP00000235345 | ENSP00000318960 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. | 0.662 |
SLC35D1 | SLC35E3 | ENSP00000235345 | ENSP00000381089 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.482 |
SLC35D1 | SLC35G1 | ENSP00000235345 | ENSP00000400932 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. | 0.480 |
SLC35E3 | C15orf40 | ENSP00000381089 | ENSP00000403987 | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.779 |