node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4orf3 | CALM1 | ENSP00000382026 | ENSP00000499717 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Calmodulin-1; Calmodulin 1; Belongs to the calmodulin family. | 0.458 |
C4orf3 | DEGS1 | ENSP00000382026 | ENSP00000316476 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.475 |
C4orf3 | EDC4 | ENSP00000382026 | ENSP00000351811 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). | 0.457 |
C4orf3 | FAM162A | ENSP00000382026 | ENSP00000419088 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. | 0.450 |
C4orf3 | GCN1 | ENSP00000382026 | ENSP00000300648 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...] | 0.422 |
C4orf3 | MRLN | ENSP00000382026 | ENSP00000488748 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | 0.676 |
C4orf3 | PANX1 | ENSP00000382026 | ENSP00000227638 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. | 0.538 |
C4orf3 | SLN | ENSP00000382026 | ENSP00000435380 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | 0.587 |
C4orf3 | SMIM6 | ENSP00000382026 | ENSP00000463361 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Small integral membrane protein 6. | 0.804 |
C4orf3 | STRIT1 | ENSP00000382026 | ENSP00000489859 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). | 0.684 |
CALM1 | C4orf3 | ENSP00000499717 | ENSP00000382026 | Calmodulin-1; Calmodulin 1; Belongs to the calmodulin family. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.458 |
DEGS1 | C4orf3 | ENSP00000316476 | ENSP00000382026 | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.475 |
EDC4 | C4orf3 | ENSP00000351811 | ENSP00000382026 | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.457 |
EDC4 | GCN1 | ENSP00000351811 | ENSP00000300648 | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...] | 0.527 |
FAM162A | C4orf3 | ENSP00000419088 | ENSP00000382026 | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.450 |
GCN1 | C4orf3 | ENSP00000300648 | ENSP00000382026 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...] | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.422 |
GCN1 | EDC4 | ENSP00000300648 | ENSP00000351811 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...] | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). | 0.527 |
MRLN | C4orf3 | ENSP00000488748 | ENSP00000382026 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.676 |
MRLN | SLN | ENSP00000488748 | ENSP00000435380 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | 0.755 |
MRLN | SMIM6 | ENSP00000488748 | ENSP00000463361 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Small integral membrane protein 6. | 0.714 |