node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUZD1 | RNF222 | ENSP00000376540 | ENSP00000382330 | CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. | Ring finger protein 222. | 0.432 |
CYP4F8 | PLA2G4D | ENSP00000477567 | ENSP00000290472 | Cytochrome P450 4F8; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions. Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predomi [...] | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | 0.755 |
CYP4F8 | RNF222 | ENSP00000477567 | ENSP00000382330 | Cytochrome P450 4F8; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions. Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predomi [...] | Ring finger protein 222. | 0.428 |
GABRP | RNF222 | ENSP00000430100 | ENSP00000382330 | Gamma-aminobutyric acid receptor subunit pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfa [...] | Ring finger protein 222. | 0.413 |
MUC15 | RNF222 | ENSP00000431983 | ENSP00000382330 | Mucin-15; May play a role in the cell adhesion to the extracellular matrix. | Ring finger protein 222. | 0.425 |
PI15 | RNF222 | ENSP00000260113 | ENSP00000382330 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Ring finger protein 222. | 0.454 |
PLA2G4D | CYP4F8 | ENSP00000290472 | ENSP00000477567 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | Cytochrome P450 4F8; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions. Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predomi [...] | 0.755 |
PLA2G4D | RNF222 | ENSP00000290472 | ENSP00000382330 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | Ring finger protein 222. | 0.454 |
RNF222 | CUZD1 | ENSP00000382330 | ENSP00000376540 | Ring finger protein 222. | CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. | 0.432 |
RNF222 | CYP4F8 | ENSP00000382330 | ENSP00000477567 | Ring finger protein 222. | Cytochrome P450 4F8; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions. Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predomi [...] | 0.428 |
RNF222 | GABRP | ENSP00000382330 | ENSP00000430100 | Ring finger protein 222. | Gamma-aminobutyric acid receptor subunit pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfa [...] | 0.413 |
RNF222 | MUC15 | ENSP00000382330 | ENSP00000431983 | Ring finger protein 222. | Mucin-15; May play a role in the cell adhesion to the extracellular matrix. | 0.425 |
RNF222 | PI15 | ENSP00000382330 | ENSP00000260113 | Ring finger protein 222. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.454 |
RNF222 | PLA2G4D | ENSP00000382330 | ENSP00000290472 | Ring finger protein 222. | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | 0.454 |
RNF222 | SAMD1 | ENSP00000382330 | ENSP00000431971 | Ring finger protein 222. | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall. | 0.471 |
RNF222 | SEZ6L | ENSP00000382330 | ENSP00000248933 | Ring finger protein 222. | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons. | 0.574 |
RNF222 | TMEM220 | ENSP00000382330 | ENSP00000339830 | Ring finger protein 222. | Transmembrane protein 220. | 0.526 |
RNF222 | ZZEF1 | ENSP00000382330 | ENSP00000371051 | Ring finger protein 222. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.477 |
SAMD1 | RNF222 | ENSP00000431971 | ENSP00000382330 | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall. | Ring finger protein 222. | 0.471 |
SEZ6L | RNF222 | ENSP00000248933 | ENSP00000382330 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons. | Ring finger protein 222. | 0.574 |