ANKRD18A protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRA2	ANKRD18A	ENSP00000296785	ENSP00000382610	Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity).	Ankyrin repeat domain 18A.	0.400
ANKRD18A	ANKRA2	ENSP00000382610	ENSP00000296785	Ankyrin repeat domain 18A.	Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity).	0.400
ANKRD18A	ASB9	ENSP00000382610	ENSP00000369855	Ankyrin repeat domain 18A.	Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A; Belongs to the ankyrin SOCS box (ASB) family.	0.431
ANKRD18A	C22orf31	ENSP00000382610	ENSP00000216071	Ankyrin repeat domain 18A.	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	0.400
ANKRD18A	FAM240B	ENSP00000382610	ENSP00000490097	Ankyrin repeat domain 18A.	Protein FAM240B; Family with sequence similarity 240 member B; Belongs to the FAM240 family.	0.540
ANKRD18A	KIF20A	ENSP00000382610	ENSP00000378356	Ankyrin repeat domain 18A.	Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility.	0.457
ANKRD18A	NOP9	ENSP00000382610	ENSP00000267425	Ankyrin repeat domain 18A.	NOP9 nucleolar protein.	0.456
ANKRD18A	RFXANK	ENSP00000382610	ENSP00000305071	Ankyrin repeat domain 18A.	DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity).	0.436
ANKRD18A	RNF123	ENSP00000382610	ENSP00000328287	Ankyrin repeat domain 18A.	E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.	0.457
ASB9	ANKRD18A	ENSP00000369855	ENSP00000382610	Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A; Belongs to the ankyrin SOCS box (ASB) family.	Ankyrin repeat domain 18A.	0.431
ASB9	RFXANK	ENSP00000369855	ENSP00000305071	Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A; Belongs to the ankyrin SOCS box (ASB) family.	DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity).	0.524
C22orf31	ANKRD18A	ENSP00000216071	ENSP00000382610	Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.	Ankyrin repeat domain 18A.	0.400
FAM240B	ANKRD18A	ENSP00000490097	ENSP00000382610	Protein FAM240B; Family with sequence similarity 240 member B; Belongs to the FAM240 family.	Ankyrin repeat domain 18A.	0.540
KIF20A	ANKRD18A	ENSP00000378356	ENSP00000382610	Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility.	Ankyrin repeat domain 18A.	0.457
NOP9	ANKRD18A	ENSP00000267425	ENSP00000382610	NOP9 nucleolar protein.	Ankyrin repeat domain 18A.	0.456
RFXANK	ANKRD18A	ENSP00000305071	ENSP00000382610	DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity).	Ankyrin repeat domain 18A.	0.436
RFXANK	ASB9	ENSP00000305071	ENSP00000369855	DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity).	Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A; Belongs to the ankyrin SOCS box (ASB) family.	0.524
RNF123	ANKRD18A	ENSP00000328287	ENSP00000382610	E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.	Ankyrin repeat domain 18A.	0.457