Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FAM166BProtein FAM166B; Family with sequence similarity 166 member B; Belongs to the UPF0605 family. (275 aa)    
Predicted Functional Partners:
C9orf116
UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.
   
 
 0.911
FAM183A
Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family.
   
   0.910
MNS1
Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.
   
 
 0.903
C9orf135
Protein C9orf135; Chromosome 9 open reading frame 135.
   
   0.899
CFAP52
Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.
   
 
 0.890
ENKUR
Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.
   
   0.888
CCDC173
Coiled-coil domain containing 173.
   
   0.886
CFAP126
Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
   
   0.884
EFHB
EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.
   
   0.880
FAM166C
Protein FAM166C; Family with sequence similarity 166 member C; Belongs to the FAM166C family.
   
 
 0.879
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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