node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C10orf120 | ENHO | ENSP00000331012 | ENSP00000382675 | Uncharacterized protein C10orf120; Chromosome 10 open reading frame 120. | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | 0.461 |
CNTN6 | ENHO | ENSP00000407822 | ENSP00000382675 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | 0.479 |
CNTN6 | GPR19 | ENSP00000407822 | ENSP00000498976 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | Probable G-protein coupled receptor 19; Orphan receptor. | 0.453 |
DCTN3 | ENHO | ENSP00000259632 | ENSP00000382675 | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | 0.469 |
DCTN3 | FAM219A | ENSP00000259632 | ENSP00000499069 | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | Protein FAM219A; Family with sequence similarity 219 member A. | 0.590 |
DCTN3 | RPP25L | ENSP00000259632 | ENSP00000297613 | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP. | 0.697 |
ENHO | C10orf120 | ENSP00000382675 | ENSP00000331012 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Uncharacterized protein C10orf120; Chromosome 10 open reading frame 120. | 0.461 |
ENHO | CNTN6 | ENSP00000382675 | ENSP00000407822 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | 0.479 |
ENHO | DCTN3 | ENSP00000382675 | ENSP00000259632 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.469 |
ENHO | FAM219A | ENSP00000382675 | ENSP00000499069 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Protein FAM219A; Family with sequence similarity 219 member A. | 0.576 |
ENHO | FNDC5 | ENSP00000382675 | ENSP00000362570 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Fibronectin type III domain-containing protein 5; [Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. | 0.608 |
ENHO | GPR19 | ENSP00000382675 | ENSP00000498976 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Probable G-protein coupled receptor 19; Orphan receptor. | 0.903 |
ENHO | INS | ENSP00000382675 | ENSP00000380432 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.448 |
ENHO | NOS3 | ENSP00000382675 | ENSP00000297494 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets; Belongs to the NOS family. | 0.410 |
ENHO | PDK4 | ENSP00000382675 | ENSP00000005178 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] | 0.416 |
ENHO | RPP25L | ENSP00000382675 | ENSP00000297613 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP. | 0.527 |
FAM219A | DCTN3 | ENSP00000499069 | ENSP00000259632 | Protein FAM219A; Family with sequence similarity 219 member A. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.590 |
FAM219A | ENHO | ENSP00000499069 | ENSP00000382675 | Protein FAM219A; Family with sequence similarity 219 member A. | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | 0.576 |
FAM219A | RPP25L | ENSP00000499069 | ENSP00000297613 | Protein FAM219A; Family with sequence similarity 219 member A. | Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP. | 0.664 |
FNDC5 | ENHO | ENSP00000362570 | ENSP00000382675 | Fibronectin type III domain-containing protein 5; [Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism. | 0.608 |