FAM234A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEH	FAM234A	ENSP00000296456	ENSP00000382814	Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family.	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	0.469
APEH	TRIM67	ENSP00000296456	ENSP00000355613	Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
C16orf58	FAM234A	ENSP00000317579	ENSP00000382814	RUS1 family protein C16orf58.	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	0.538
C16orf58	RNF4	ENSP00000317579	ENSP00000426503	RUS1 family protein C16orf58.	E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...]	0.457
C16orf58	TRIM67	ENSP00000317579	ENSP00000355613	RUS1 family protein C16orf58.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
FAM234A	APEH	ENSP00000382814	ENSP00000296456	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family.	0.469
FAM234A	C16orf58	ENSP00000382814	ENSP00000317579	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	RUS1 family protein C16orf58.	0.538
FAM234A	LMBR1L	ENSP00000382814	ENSP00000267102	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.	0.471
FAM234A	LUC7L	ENSP00000382814	ENSP00000293872	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	0.511
FAM234A	OXLD1	ENSP00000382814	ENSP00000363873	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1.	0.565
FAM234A	RNF4	ENSP00000382814	ENSP00000426503	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular [...]	0.460
FAM234A	SNX27	ENSP00000382814	ENSP00000400333	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...]	0.457
FAM234A	STX12	ENSP00000382814	ENSP00000363054	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family.	0.772
FAM234A	TRIM67	ENSP00000382814	ENSP00000355613	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
FAM234A	XKRX	ENSP00000382814	ENSP00000362047	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	XK-related protein 2; XK related X-linked.	0.528
LMBR1L	FAM234A	ENSP00000267102	ENSP00000382814	Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	0.471
LMBR1L	STX12	ENSP00000267102	ENSP00000363054	Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family.	0.497
LUC7L	FAM234A	ENSP00000293872	ENSP00000382814	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	0.511
LUC7L	TRIM67	ENSP00000293872	ENSP00000355613	Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
OXLD1	FAM234A	ENSP00000363873	ENSP00000382814	Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1.	Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.	0.565