node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERMP1 | KIAA2026 | ENSP00000340427 | ENSP00000382815 | Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family. | Uncharacterized protein KIAA2026; KIAA2026. | 0.612 |
ERMP1 | RIC1 | ENSP00000340427 | ENSP00000416696 | Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.675 |
ERMP1 | SLC16A13 | ENSP00000340427 | ENSP00000309751 | Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family. | Monocarboxylate transporter 13; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. | 0.416 |
ETAA1 | KIAA2026 | ENSP00000272342 | ENSP00000382815 | Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. | Uncharacterized protein KIAA2026; KIAA2026. | 0.481 |
ETAA1 | MKLN1 | ENSP00000272342 | ENSP00000323527 | Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. | 0.411 |
KIAA2026 | ERMP1 | ENSP00000382815 | ENSP00000340427 | Uncharacterized protein KIAA2026; KIAA2026. | Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family. | 0.612 |
KIAA2026 | ETAA1 | ENSP00000382815 | ENSP00000272342 | Uncharacterized protein KIAA2026; KIAA2026. | Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. | 0.481 |
KIAA2026 | MKLN1 | ENSP00000382815 | ENSP00000323527 | Uncharacterized protein KIAA2026; KIAA2026. | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. | 0.470 |
KIAA2026 | NUDT11 | ENSP00000382815 | ENSP00000365160 | Uncharacterized protein KIAA2026; KIAA2026. | Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; Belongs to the Nudix hydrolase family. DIPP subfamily. | 0.438 |
KIAA2026 | PLGRKT | ENSP00000382815 | ENSP00000223864 | Uncharacterized protein KIAA2026; KIAA2026. | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. | 0.457 |
KIAA2026 | RANBP6 | ENSP00000382815 | ENSP00000259569 | Uncharacterized protein KIAA2026; KIAA2026. | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor. | 0.457 |
KIAA2026 | RIC1 | ENSP00000382815 | ENSP00000416696 | Uncharacterized protein KIAA2026; KIAA2026. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.711 |
KIAA2026 | SLC16A13 | ENSP00000382815 | ENSP00000309751 | Uncharacterized protein KIAA2026; KIAA2026. | Monocarboxylate transporter 13; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. | 0.509 |
KIAA2026 | SLC66A3 | ENSP00000382815 | ENSP00000295083 | Uncharacterized protein KIAA2026; KIAA2026. | Solute carrier family 66 member 3. | 0.516 |
KIAA2026 | UBTD1 | ENSP00000382815 | ENSP00000359698 | Uncharacterized protein KIAA2026; KIAA2026. | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. | 0.555 |
MKLN1 | ETAA1 | ENSP00000323527 | ENSP00000272342 | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. | Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. | 0.411 |
MKLN1 | KIAA2026 | ENSP00000323527 | ENSP00000382815 | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. | Uncharacterized protein KIAA2026; KIAA2026. | 0.470 |
NUDT11 | KIAA2026 | ENSP00000365160 | ENSP00000382815 | Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; Belongs to the Nudix hydrolase family. DIPP subfamily. | Uncharacterized protein KIAA2026; KIAA2026. | 0.438 |
PLGRKT | KIAA2026 | ENSP00000223864 | ENSP00000382815 | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. | Uncharacterized protein KIAA2026; KIAA2026. | 0.457 |
PLGRKT | RIC1 | ENSP00000223864 | ENSP00000416696 | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.493 |