STRINGSTRING
SIAH3 protein (human) - STRING interaction network
"SIAH3" - Seven in absentia homolog 3 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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SIAH3Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria (269 aa)    
Predicted Functional Partners:
TOMM7
Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria; Belongs to the Tom7 family (55 aa)
           
  0.702
BAG4
BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria; BCL2 associated athanogene family (457 aa)
           
  0.658
HSPA1L
Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (641 aa)
       
 
  0.591
USP15
Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF- beta target genes. According to another reports, regulates the TGF-beta [...] (981 aa)
       
 
  0.555
FAM217A
Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family (508 aa)
           
  0.534
IGFL3
Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor (125 aa)
           
  0.526
OR6M1
Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 (313 aa)
           
  0.511
OR8H3
Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 (312 aa)
           
  0.510
UBE2U
Ubiquitin-conjugating enzyme E2 U; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family (226 aa)
     
 
  0.508
RSPH10B2
Radial spoke head 10 homolog B2 (870 aa)
     
   
  0.487
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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