C9orf152 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf116	C9orf152	ENSP00000352447	ENSP00000383456	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	0.512
C1orf116	KIAA0040	ENSP00000352447	ENSP00000462172	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	Uncharacterized protein KIAA0040; KIAA0040.	0.479
C1orf116	PAK1IP1	ENSP00000352447	ENSP00000368887	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	0.421
C1orf116	PRR15L	ENSP00000352447	ENSP00000300557	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family.	0.533
C9orf152	C1orf116	ENSP00000383456	ENSP00000352447	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	0.512
C9orf152	IL10RA	ENSP00000383456	ENSP00000227752	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Interleukin-10 receptor subunit alpha; Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellul [...]	0.451
C9orf152	KIAA0040	ENSP00000383456	ENSP00000462172	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Uncharacterized protein KIAA0040; KIAA0040.	0.485
C9orf152	PAK1IP1	ENSP00000383456	ENSP00000368887	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	0.413
C9orf152	PIK3AP1	ENSP00000383456	ENSP00000339826	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival o [...]	0.419
C9orf152	PRR15L	ENSP00000383456	ENSP00000300557	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family.	0.605
C9orf152	RAB30	ENSP00000383456	ENSP00000435189	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.	0.437
C9orf152	SLFNL1	ENSP00000383456	ENSP00000352299	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Schlafen-like protein 1; Schlafen like 1.	0.436
C9orf152	SMKR1	ENSP00000383456	ENSP00000454370	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Small lysine rich protein 1.	0.450
C9orf152	TMED6	ENSP00000383456	ENSP00000288025	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	Transmembrane p24 trafficking protein 6.	0.493
IL10RA	C9orf152	ENSP00000227752	ENSP00000383456	Interleukin-10 receptor subunit alpha; Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellul [...]	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	0.451
KIAA0040	C1orf116	ENSP00000462172	ENSP00000352447	Uncharacterized protein KIAA0040; KIAA0040.	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	0.479
KIAA0040	C9orf152	ENSP00000462172	ENSP00000383456	Uncharacterized protein KIAA0040; KIAA0040.	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	0.485
KIAA0040	PRR15L	ENSP00000462172	ENSP00000300557	Uncharacterized protein KIAA0040; KIAA0040.	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family.	0.467
PAK1IP1	C1orf116	ENSP00000368887	ENSP00000352447	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.	0.421
PAK1IP1	C9orf152	ENSP00000368887	ENSP00000383456	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.	0.413