node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAH11 | TMEM196 | ENSP00000475939 | ENSP00000385087 | Dynein heavy chain 11, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. | Transmembrane protein 196. | 0.534 |
ITGB8 | TMEM196 | ENSP00000222573 | ENSP00000385087 | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). | Transmembrane protein 196. | 0.485 |
KLHL25 | OR2B3 | ENSP00000336800 | ENSP00000366378 | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
KLHL25 | SLC35F4 | ENSP00000336800 | ENSP00000452086 | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | Solute carrier family 35 member F4; Putative solute transporter. | 0.529 |
KLHL25 | TMEM196 | ENSP00000336800 | ENSP00000385087 | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | Transmembrane protein 196. | 0.506 |
KLHL25 | TSR3 | ENSP00000336800 | ENSP00000007390 | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis. | 0.445 |
OR2B3 | KLHL25 | ENSP00000366378 | ENSP00000336800 | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | 0.580 |
OR2B3 | SLC35F4 | ENSP00000366378 | ENSP00000452086 | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Solute carrier family 35 member F4; Putative solute transporter. | 0.665 |
OR2B3 | STARD3NL | ENSP00000366378 | ENSP00000009041 | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB ; Belongs to the STARD3 family. | 0.540 |
OR2B3 | TMEM196 | ENSP00000366378 | ENSP00000385087 | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Transmembrane protein 196. | 0.643 |
OR2B3 | TSR3 | ENSP00000366378 | ENSP00000007390 | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis. | 0.583 |
RAPGEF5 | TMEM196 | ENSP00000343656 | ENSP00000385087 | Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. | Transmembrane protein 196. | 0.451 |
SLC35F4 | KLHL25 | ENSP00000452086 | ENSP00000336800 | Solute carrier family 35 member F4; Putative solute transporter. | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. | 0.529 |
SLC35F4 | OR2B3 | ENSP00000452086 | ENSP00000366378 | Solute carrier family 35 member F4; Putative solute transporter. | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.665 |
SLC35F4 | STARD3NL | ENSP00000452086 | ENSP00000009041 | Solute carrier family 35 member F4; Putative solute transporter. | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB ; Belongs to the STARD3 family. | 0.480 |
SLC35F4 | TMEM196 | ENSP00000452086 | ENSP00000385087 | Solute carrier family 35 member F4; Putative solute transporter. | Transmembrane protein 196. | 0.613 |
SLC35F4 | TSR3 | ENSP00000452086 | ENSP00000007390 | Solute carrier family 35 member F4; Putative solute transporter. | Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis. | 0.544 |
SP4 | TMEM196 | ENSP00000222584 | ENSP00000385087 | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator. | Transmembrane protein 196. | 0.571 |
STARD3NL | OR2B3 | ENSP00000009041 | ENSP00000366378 | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB ; Belongs to the STARD3 family. | Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.540 |
STARD3NL | SLC35F4 | ENSP00000009041 | ENSP00000452086 | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB ; Belongs to the STARD3 family. | Solute carrier family 35 member F4; Putative solute transporter. | 0.480 |