node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP11 | TNFSF11 | ENSP00000025301 | ENSP00000381775 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | 0.497 |
AKAP11 | ZBTB40 | ENSP00000025301 | ENSP00000384527 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.602 |
CCDC170 | TMEM135 | ENSP00000239374 | ENSP00000306344 | Coiled-coil domain containing 170. | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family. | 0.458 |
CCDC170 | ZBTB40 | ENSP00000239374 | ENSP00000384527 | Coiled-coil domain containing 170. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.606 |
CYP17A1 | ZBTB40 | ENSP00000358903 | ENSP00000384527 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C1 [...] | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.622 |
DCDC1 | FAM210A | ENSP00000385936 | ENSP00000323635 | Doublecortin domain-containing protein 1; Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. | Protein FAM210A; May play a role in the structure and strength of both muscle and bone. | 0.527 |
DCDC1 | ZBTB40 | ENSP00000385936 | ENSP00000384527 | Doublecortin domain-containing protein 1; Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.580 |
FAM210A | DCDC1 | ENSP00000323635 | ENSP00000385936 | Protein FAM210A; May play a role in the structure and strength of both muscle and bone. | Doublecortin domain-containing protein 1; Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. | 0.527 |
FAM210A | ZBTB40 | ENSP00000323635 | ENSP00000384527 | Protein FAM210A; May play a role in the structure and strength of both muscle and bone. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.592 |
LRP5 | TNFSF11 | ENSP00000294304 | ENSP00000381775 | Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone [...] | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | 0.800 |
LRP5 | ZBTB40 | ENSP00000294304 | ENSP00000384527 | Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone [...] | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.682 |
MEGF6 | WRAP73 | ENSP00000348982 | ENSP00000270708 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | 0.889 |
MEGF6 | ZBTB40 | ENSP00000348982 | ENSP00000384527 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.776 |
TMEM135 | CCDC170 | ENSP00000306344 | ENSP00000239374 | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family. | Coiled-coil domain containing 170. | 0.458 |
TMEM135 | ZBTB40 | ENSP00000306344 | ENSP00000384527 | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family. | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.556 |
TNFSF11 | AKAP11 | ENSP00000381775 | ENSP00000025301 | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | 0.497 |
TNFSF11 | LRP5 | ENSP00000381775 | ENSP00000294304 | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone [...] | 0.800 |
TNFSF11 | ZBTB40 | ENSP00000381775 | ENSP00000384527 | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.584 |
WRAP73 | MEGF6 | ENSP00000270708 | ENSP00000348982 | WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | 0.889 |
WRAP73 | ZBTB40 | ENSP00000270708 | ENSP00000384527 | WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation. | 0.830 |