Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM24A | GAREM2 | ENSP00000357889 | ENSP00000384593 | Protein FAM24A; Family with sequence similarity 24 member A. | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | 0.511 |
| GAREM1 | GAREM2 | ENSP00000269209 | ENSP00000384593 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | 0.637 |
| GAREM1 | GDI1 | ENSP00000269209 | ENSP00000394071 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.506 |
| GAREM1 | GDI2 | ENSP00000269209 | ENSP00000369538 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.506 |
| GAREM1 | GRB2 | ENSP00000269209 | ENSP00000376345 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.975 |
| GAREM1 | RAB3IL1 | ENSP00000269209 | ENSP00000378313 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. Belongs to the SEC2 family. | 0.481 |
| GAREM1 | RAB3IP | ENSP00000269209 | ENSP00000447300 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | 0.486 |
| GAREM1 | THEMIS2 | ENSP00000269209 | ENSP00000363031 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production. | 0.464 |
| GAREM1 | VPS16 | ENSP00000269209 | ENSP00000369810 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] | 0.487 |
| GAREM2 | FAM24A | ENSP00000384593 | ENSP00000357889 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Protein FAM24A; Family with sequence similarity 24 member A. | 0.511 |
| GAREM2 | GAREM1 | ENSP00000384593 | ENSP00000269209 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | 0.637 |
| GAREM2 | GDI1 | ENSP00000384593 | ENSP00000394071 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.506 |
| GAREM2 | GDI2 | ENSP00000384593 | ENSP00000369538 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.506 |
| GAREM2 | GRB2 | ENSP00000384593 | ENSP00000376345 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.816 |
| GAREM2 | RAB3IL1 | ENSP00000384593 | ENSP00000378313 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. Belongs to the SEC2 family. | 0.486 |
| GAREM2 | RAB3IP | ENSP00000384593 | ENSP00000447300 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | 0.481 |
| GAREM2 | THEMIS2 | ENSP00000384593 | ENSP00000363031 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production. | 0.474 |
| GAREM2 | VPS16 | ENSP00000384593 | ENSP00000369810 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] | 0.487 |
| GAREM2 | ZNF562 | ENSP00000384593 | ENSP00000410734 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.451 |
| GDI1 | GAREM1 | ENSP00000394071 | ENSP00000269209 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. | 0.506 |
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