| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPLX1 | PIGG | ENSP00000305613 | ENSP00000415203 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. | 0.469 |
| CPLX1 | SLC49A3 | ENSP00000305613 | ENSP00000384616 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.527 |
| METTL27 | SLC49A3 | ENSP00000297873 | ENSP00000384616 | Methyltransferase-like protein 27; Methyltransferase like 27. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.423 |
| MFSD1 | MFSD8 | ENSP00000484175 | ENSP00000493218 | Major facilitator superfamily domain containing 1. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients. | 0.502 |
| MFSD1 | SLC49A3 | ENSP00000484175 | ENSP00000384616 | Major facilitator superfamily domain containing 1. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.505 |
| MFSD8 | MFSD1 | ENSP00000493218 | ENSP00000484175 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients. | Major facilitator superfamily domain containing 1. | 0.502 |
| MFSD8 | SLC49A3 | ENSP00000493218 | ENSP00000384616 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.452 |
| PCGF3 | SLC49A3 | ENSP00000354724 | ENSP00000384616 | Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1- like complex that mediates mon [...] | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.495 |
| PIGG | CPLX1 | ENSP00000415203 | ENSP00000305613 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | 0.469 |
| PIGG | SLC49A3 | ENSP00000415203 | ENSP00000384616 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.546 |
| SLC29A3 | SLC49A3 | ENSP00000362285 | ENSP00000384616 | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.475 |
| SLC3A2 | SLC49A3 | ENSP00000367123 | ENSP00000384616 | 4F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer. The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids. The complexes function as amino acid exchangers. Required for targeting of SLC7A5 and SLC7A8 to the p [...] | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 0.409 |
| SLC49A3 | CPLX1 | ENSP00000384616 | ENSP00000305613 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | 0.527 |
| SLC49A3 | METTL27 | ENSP00000384616 | ENSP00000297873 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Methyltransferase-like protein 27; Methyltransferase like 27. | 0.423 |
| SLC49A3 | MFSD1 | ENSP00000384616 | ENSP00000484175 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Major facilitator superfamily domain containing 1. | 0.505 |
| SLC49A3 | MFSD8 | ENSP00000384616 | ENSP00000493218 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients. | 0.452 |
| SLC49A3 | PCGF3 | ENSP00000384616 | ENSP00000354724 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1- like complex that mediates mon [...] | 0.495 |
| SLC49A3 | PIGG | ENSP00000384616 | ENSP00000415203 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. | 0.546 |
| SLC49A3 | SLC29A3 | ENSP00000384616 | ENSP00000362285 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. | 0.475 |
| SLC49A3 | SLC3A2 | ENSP00000384616 | ENSP00000367123 | Solute carrier family 49 member 3; Belongs to the major facilitator superfamily. | 4F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer. The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids. The complexes function as amino acid exchangers. Required for targeting of SLC7A5 and SLC7A8 to the p [...] | 0.409 |
