node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA1 | ZDHHC8 | ENSP00000363868 | ENSP00000384716 | Phospholipid-transporting ATPase ABCA1; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs ; Belongs to the ABC transporter superfamily. ABCA family. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.773 |
COMT | DGCR2 | ENSP00000354511 | ENSP00000263196 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | 0.689 |
COMT | LOC102724788 | ENSP00000354511 | ENSP00000481127 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.894 |
COMT | MRPL40 | ENSP00000354511 | ENSP00000333401 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. | 0.409 |
COMT | PRODH | ENSP00000354511 | ENSP00000349577 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.890 |
COMT | TANGO2 | ENSP00000354511 | ENSP00000403645 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Transport and golgi organization 2 homolog. | 0.435 |
COMT | ZDHHC8 | ENSP00000354511 | ENSP00000384716 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.814 |
DGCR2 | COMT | ENSP00000263196 | ENSP00000354511 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.689 |
DGCR2 | LOC102724788 | ENSP00000263196 | ENSP00000481127 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.779 |
DGCR2 | MRPL40 | ENSP00000263196 | ENSP00000333401 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. | 0.608 |
DGCR2 | PRODH | ENSP00000263196 | ENSP00000349577 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.767 |
DGCR2 | RTN4R | ENSP00000263196 | ENSP00000043402 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain develo [...] | 0.449 |
DGCR2 | TANGO2 | ENSP00000263196 | ENSP00000403645 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Transport and golgi organization 2 homolog. | 0.532 |
DGCR2 | ZDHHC8 | ENSP00000263196 | ENSP00000384716 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.769 |
GOLGA7 | ZDHHC8 | ENSP00000350378 | ENSP00000384716 | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.700 |
LOC102724788 | COMT | ENSP00000481127 | ENSP00000354511 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.894 |
LOC102724788 | DGCR2 | ENSP00000481127 | ENSP00000263196 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. | 0.779 |
LOC102724788 | MRPL40 | ENSP00000481127 | ENSP00000333401 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. | 0.681 |
LOC102724788 | PRODH | ENSP00000481127 | ENSP00000349577 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.901 |
LOC102724788 | RTN4R | ENSP00000481127 | ENSP00000043402 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain develo [...] | 0.595 |