STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RSPH10B2Radial spoke head 10 homolog B2. (870 aa)    
Predicted Functional Partners:
RSPH10B
Radial spoke head 10 homolog B.
  
  
0.999
ANKRD61
Ankyrin repeat domain 61.
    
 
 0.604
BOLA2-SMG1P6
BOLA2-SMG1P6 readthrough.
      
 0.582
FAM217A
Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family.
      
 0.543
CCDC81
Coiled-coil domain containing 81.
   
  
 0.528
PMS2
Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing th [...]
 
    
 0.511
RSPH9
Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.
   
 
 0.511
OR6M1
Olfactory receptor 6M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.507
OR8H3
Olfactory receptor 8H3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.480
ZNF853
Zinc finger protein 853.
    
 
 0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.