node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC65 | DRC1 | ENSP00000312706 | ENSP00000288710 | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.924 |
CCDC65 | FAM161A | ENSP00000312706 | ENSP00000385158 | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family | Protein FAM161A; Involved in ciliogenesis | 0.698 |
CCDC65 | SPEF2 | ENSP00000312706 | ENSP00000348314 | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family | Sperm flagellar protein 2; Required for correct axoneme development | 0.600 |
CERKL | CNGA1 | ENSP00000341159 | ENSP00000384264 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | 0.672 |
CERKL | FAM161A | ENSP00000341159 | ENSP00000385158 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | Protein FAM161A; Involved in ciliogenesis | 0.683 |
CERKL | LCA5 | ENSP00000341159 | ENSP00000376686 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | Lebercilin; Might be involved in minus end-directed microtubule transport | 0.629 |
CERKL | ZNF513 | ENSP00000341159 | ENSP00000318373 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance; Zinc fingers C2H2-type | 0.619 |
CNGA1 | CERKL | ENSP00000384264 | ENSP00000341159 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | 0.672 |
CNGA1 | FAM161A | ENSP00000384264 | ENSP00000385158 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | Protein FAM161A; Involved in ciliogenesis | 0.828 |
CNGA1 | LCA5 | ENSP00000384264 | ENSP00000376686 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | Lebercilin; Might be involved in minus end-directed microtubule transport | 0.473 |
CNGA1 | POU6F2 | ENSP00000384264 | ENSP00000384004 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA; Belongs to the POU transcription factor family. Class- 6 subfamily | 0.656 |
CNGA1 | ZNF513 | ENSP00000384264 | ENSP00000318373 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance; Zinc fingers C2H2-type | 0.511 |
DRC1 | CCDC65 | ENSP00000288710 | ENSP00000312706 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family | 0.924 |
DRC1 | FAM161A | ENSP00000288710 | ENSP00000385158 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Protein FAM161A; Involved in ciliogenesis | 0.673 |
DRC1 | SPEF2 | ENSP00000288710 | ENSP00000348314 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Sperm flagellar protein 2; Required for correct axoneme development | 0.612 |
FAM161A | CCDC65 | ENSP00000385158 | ENSP00000312706 | Protein FAM161A; Involved in ciliogenesis | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family | 0.698 |
FAM161A | CERKL | ENSP00000385158 | ENSP00000341159 | Protein FAM161A; Involved in ciliogenesis | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions | 0.683 |
FAM161A | CNGA1 | ENSP00000385158 | ENSP00000384264 | Protein FAM161A; Involved in ciliogenesis | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily | 0.828 |
FAM161A | DRC1 | ENSP00000385158 | ENSP00000288710 | Protein FAM161A; Involved in ciliogenesis | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.673 |
FAM161A | LCA5 | ENSP00000385158 | ENSP00000376686 | Protein FAM161A; Involved in ciliogenesis | Lebercilin; Might be involved in minus end-directed microtubule transport | 0.858 |