FAM161A protein (human) - STRING interaction network

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FAM161A

Protein FAM161A; Involved in ciliogenesis (716 aa)

Predicted Functional Partners:

LCA5

0.858

CNGA1

0.828

POC1B

0.763

SDCCAG8

0.722

CCDC65

0.698

CERKL

0.683

SPEF2

0.679

POU6F2

0.677

DRC1

0.673

ZNF513

0.671

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC65	DRC1	ENSP00000312706	ENSP00000288710	Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family	Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	0.924
CCDC65	FAM161A	ENSP00000312706	ENSP00000385158	Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family	Protein FAM161A; Involved in ciliogenesis	0.698
CCDC65	SPEF2	ENSP00000312706	ENSP00000348314	Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family	Sperm flagellar protein 2; Required for correct axoneme development	0.600
CERKL	CNGA1	ENSP00000341159	ENSP00000384264	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	0.672
CERKL	FAM161A	ENSP00000341159	ENSP00000385158	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	Protein FAM161A; Involved in ciliogenesis	0.683
CERKL	LCA5	ENSP00000341159	ENSP00000376686	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	Lebercilin; Might be involved in minus end-directed microtubule transport	0.629
CERKL	ZNF513	ENSP00000341159	ENSP00000318373	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance; Zinc fingers C2H2-type	0.619
CNGA1	CERKL	ENSP00000384264	ENSP00000341159	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	0.672
CNGA1	FAM161A	ENSP00000384264	ENSP00000385158	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	Protein FAM161A; Involved in ciliogenesis	0.828
CNGA1	LCA5	ENSP00000384264	ENSP00000376686	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	Lebercilin; Might be involved in minus end-directed microtubule transport	0.473
CNGA1	POU6F2	ENSP00000384264	ENSP00000384004	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5’-ATGCAAAT-3’. Isoform 1 does not bind DNA; Belongs to the POU transcription factor family. Class- 6 subfamily	0.656
CNGA1	ZNF513	ENSP00000384264	ENSP00000318373	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance; Zinc fingers C2H2-type	0.511
DRC1	CCDC65	ENSP00000288710	ENSP00000312706	Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family	0.924
DRC1	FAM161A	ENSP00000288710	ENSP00000385158	Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	Protein FAM161A; Involved in ciliogenesis	0.673
DRC1	SPEF2	ENSP00000288710	ENSP00000348314	Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	Sperm flagellar protein 2; Required for correct axoneme development	0.612
FAM161A	CCDC65	ENSP00000385158	ENSP00000312706	Protein FAM161A; Involved in ciliogenesis	Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family	0.698
FAM161A	CERKL	ENSP00000385158	ENSP00000341159	Protein FAM161A; Involved in ciliogenesis	Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions	0.683
FAM161A	CNGA1	ENSP00000385158	ENSP00000384264	Protein FAM161A; Involved in ciliogenesis	cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily	0.828
FAM161A	DRC1	ENSP00000385158	ENSP00000288710	Protein FAM161A; Involved in ciliogenesis	Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	0.673
FAM161A	LCA5	ENSP00000385158	ENSP00000376686	Protein FAM161A; Involved in ciliogenesis	Lebercilin; Might be involved in minus end-directed microtubule transport	0.858

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