node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN14 | CAPNS1 | ENSP00000385247 | ENSP00000464849 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.688 |
CAPN14 | CAPNS2 | ENSP00000385247 | ENSP00000400882 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.684 |
CAPN14 | CAST | ENSP00000385247 | ENSP00000422176 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.744 |
CAPN14 | CCL26 | ENSP00000385247 | ENSP00000378365 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. | 0.667 |
CAPN14 | CDH26 | ENSP00000385247 | ENSP00000339390 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Cadherin-like protein 26; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation. | 0.607 |
CAPN14 | DSG1 | ENSP00000385247 | ENSP00000257192 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.700 |
CAPN14 | FLG | ENSP00000385247 | ENSP00000357789 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.617 |
CAPN14 | FLG2 | ENSP00000385247 | ENSP00000373370 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | 0.613 |
CAPN14 | SPINK7 | ENSP00000385247 | ENSP00000274565 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. | 0.617 |
CAPN14 | TSLP | ENSP00000385247 | ENSP00000339804 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | Thymic stromal lymphopoietin; [Isoform 1]: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. | 0.625 |
CAPNS1 | CAPN14 | ENSP00000464849 | ENSP00000385247 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | 0.688 |
CAPNS1 | CAPNS2 | ENSP00000464849 | ENSP00000400882 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.885 |
CAPNS1 | CAST | ENSP00000464849 | ENSP00000422176 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.995 |
CAPNS1 | FLG | ENSP00000464849 | ENSP00000357789 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.420 |
CAPNS2 | CAPN14 | ENSP00000400882 | ENSP00000385247 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | 0.684 |
CAPNS2 | CAPNS1 | ENSP00000400882 | ENSP00000464849 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.885 |
CAPNS2 | CAST | ENSP00000400882 | ENSP00000422176 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.929 |
CAST | CAPN14 | ENSP00000422176 | ENSP00000385247 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain-14; Calcium-regulated non-lysosomal thiol-protease. | 0.744 |
CAST | CAPNS1 | ENSP00000422176 | ENSP00000464849 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.995 |
CAST | CAPNS2 | ENSP00000422176 | ENSP00000400882 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.929 |